Abstract
Cytomegalovirus (CMV) was repeatedly isolated from urine and saliva of a 20-month-old male child with recurrent episodes of pneumonia, high fever, rash, lymphadenopathy, oral ulceration, and neutropenia. Immunologic evaluation revealed decreased serum IgG and IgA, increased IgM, depressed T- and B-lymphocyte functions, and decreased natural killer (NK) activity for herpes simplex-type I virus-infected targets. NK activity was augmented following exposure of the patient's lymphocytes to interferon (IF) in vitro. The child was treated with interferon (four courses, dosage varying from 2 million U/day to 1 million U three times/week for periods of 10, 28, 80, and 67 days, respectively, interspersed over 9 months) and hyperimmune plasma infusions every 3 weeks. Toward the end of interferon therapy oral Levamisole was started and a feeding gastrostomy was inserted to provide nutritional support. Clinical recovery was associated with reversal of immunologic abnormalities except for the hypogammaglobulinemia. Aggressive antiviral therapy (e.g., with IF) followed by immunostimulation (e.g., with Levamisole) may prove effective in controlling certain viral infections in immunodeficiency disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 77-89 |
| Number of pages | 13 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Persistent cytomegalovirus infection : Association with profound immunodeficiency and treatment with interferon. / Pahwa, Savita G; Kirkpatrick, Dahlia; Ching, Clara; Lopez, Carlos; Pahwa, Rajendra; Smithwick, Elizabeth; O'Reilly, Richard; August, Charles; Pasquariello, Patrick; Good, Robert A.
In: Clinical Immunology and Immunopathology, Vol. 28, No. 1, 01.01.1983, p. 77-89.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistent cytomegalovirus infection
T2 - Association with profound immunodeficiency and treatment with interferon
AU - Pahwa, Savita G
AU - Kirkpatrick, Dahlia
AU - Ching, Clara
AU - Lopez, Carlos
AU - Pahwa, Rajendra
AU - Smithwick, Elizabeth
AU - O'Reilly, Richard
AU - August, Charles
AU - Pasquariello, Patrick
AU - Good, Robert A.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Cytomegalovirus (CMV) was repeatedly isolated from urine and saliva of a 20-month-old male child with recurrent episodes of pneumonia, high fever, rash, lymphadenopathy, oral ulceration, and neutropenia. Immunologic evaluation revealed decreased serum IgG and IgA, increased IgM, depressed T- and B-lymphocyte functions, and decreased natural killer (NK) activity for herpes simplex-type I virus-infected targets. NK activity was augmented following exposure of the patient's lymphocytes to interferon (IF) in vitro. The child was treated with interferon (four courses, dosage varying from 2 million U/day to 1 million U three times/week for periods of 10, 28, 80, and 67 days, respectively, interspersed over 9 months) and hyperimmune plasma infusions every 3 weeks. Toward the end of interferon therapy oral Levamisole was started and a feeding gastrostomy was inserted to provide nutritional support. Clinical recovery was associated with reversal of immunologic abnormalities except for the hypogammaglobulinemia. Aggressive antiviral therapy (e.g., with IF) followed by immunostimulation (e.g., with Levamisole) may prove effective in controlling certain viral infections in immunodeficiency disorders.
AB - Cytomegalovirus (CMV) was repeatedly isolated from urine and saliva of a 20-month-old male child with recurrent episodes of pneumonia, high fever, rash, lymphadenopathy, oral ulceration, and neutropenia. Immunologic evaluation revealed decreased serum IgG and IgA, increased IgM, depressed T- and B-lymphocyte functions, and decreased natural killer (NK) activity for herpes simplex-type I virus-infected targets. NK activity was augmented following exposure of the patient's lymphocytes to interferon (IF) in vitro. The child was treated with interferon (four courses, dosage varying from 2 million U/day to 1 million U three times/week for periods of 10, 28, 80, and 67 days, respectively, interspersed over 9 months) and hyperimmune plasma infusions every 3 weeks. Toward the end of interferon therapy oral Levamisole was started and a feeding gastrostomy was inserted to provide nutritional support. Clinical recovery was associated with reversal of immunologic abnormalities except for the hypogammaglobulinemia. Aggressive antiviral therapy (e.g., with IF) followed by immunostimulation (e.g., with Levamisole) may prove effective in controlling certain viral infections in immunodeficiency disorders.
UR - http://www.scopus.com/inward/record.url?scp=0020576619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020576619&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(83)90190-3
DO - 10.1016/0090-1229(83)90190-3
M3 - Article
C2 - 6307574
AN - SCOPUS:0020576619
VL - 28
SP - 77
EP - 89
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -