Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents

Barry H. Trachtenberg, Andrea M. Cordero-Reyes, Molham Aldeiri, Paulino Alvarez, Arvind Bhimaraj, Guha Ashrith, Barbara Elias, Erik E. Suarez, Brian Bruckner, Matthias Loebe, Richard L. Harris, J. Yi Zhang, Guillermo Torre-Amione, Jerry D. Estep

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background Common adverse events in patients supported with Continuous-flow left ventricular assist devices (CF-LVAD) include infections and cerebrovascular accidents (CVA). Some studies have suggested a possible association between blood stream infection (BSI) and CVA. Methods and Results Medical records of patients who received Heartmate II (HMII) CF-LVADs in 2008-2012 at a single center were reviewed. CVA was categorized as either hemorrhagic (HCVA) or ischemic (ICVA). BSI was divided into persistent (pBSI) and nonpersistent (non-pBSI). pBSI was defined as BSI with the same organism on repeated blood culture >72 hours from initial blood culture despite antibiotics. Univariate and multivariate analyses were performed to determine predictors. A total of 149 patients had HMII implanted; 76% were male, and the overall mean age was 55.4 ± 13 years. There were a total of 19 (13%) patients who had CVA (7 HCVA and 12 ICVA) at a median of 295 days (range 5-1,096 days) after implantation. There were a total of 28 (19%) patients with pBSI and 17 (11%) patients with non-pBSI. Patients with pBSI had a trend toward greater BMI (31 kg/m2 vs 27 kg/m2; P =.09), and longer duration of support (1,019 d vs 371 d; P <.001) compared with those with non-pBSI. Persistent BSI was associated with an increased risk of mortality and with all-cause CVA on multivariate analysis (odds ratio [OR] 5.97; P =.003) as well as persistent Pseudomonas aeruginosa infection (OR 4.54; P =.048). Conclusions Persistent BSI is not uncommon in patients supported by CF-LVAD and is highly associated with all-cause CVA and increased all-cause mortality.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalJournal of cardiac failure
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Keywords

  • Left ventricular assist device
  • Pseudomonas aeruginosa
  • cerebrovascular accident
  • infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Trachtenberg, B. H., Cordero-Reyes, A. M., Aldeiri, M., Alvarez, P., Bhimaraj, A., Ashrith, G., Elias, B., Suarez, E. E., Bruckner, B., Loebe, M., Harris, R. L., Zhang, J. Y., Torre-Amione, G., & Estep, J. D. (2015). Persistent blood stream infection in patients supported with a continuous-flow left ventricular assist device is associated with an increased risk of cerebrovascular accidents. Journal of cardiac failure, 21(2), 119-125. https://doi.org/10.1016/j.cardfail.2014.10.019