Persistence of serum lipid abnormalities in children with idiopathic nephrotic syndrome

Gaston Zilleruelo, Sung L. Hsia, Michael Freundlich, Helen M. Gorman, Jose Strauss

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We investigated the severity and duration of hyperlipidemia in 59 nephrotic children during relapse and remission. Serum total cholesterol and triglyceride values were≥95th percentile for age and sex in all patients with minimal change nephrotic syndrome in relapse and in patients with non-MCNS and persistent proteinuria. Most of these patients also had a significant elevation of low- and very-low-density lipoproteins. A significant number of children with MCNS during prolonged remission had elevated serum concentrations of total cholesterol (46%), triglycerides (42%), LDL (29%), and VLDL (40%). Persistence and severity of lipid changes correlated well with duration of disease and frequency of relapses. Significantly decreased HDL and HDL/LDL were found in patients with non-MCNS and persistent proteinuria. Our results suggest that nephrotic children may have prolonged periods of hyperlipidemia even after clinical remission. In addition, some of these children with significantly decreased HDL/LDL may be at increased risk of developing premature atherosclerosis.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalThe Journal of Pediatrics
Volume104
Issue number1
DOIs
StatePublished - Jan 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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