Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients

Kathy Hebert, Barbara Lopez, Francisco Yuri Bulcao Macedo, Conrado Rios Gomes, Johan Urena, Lee M. Arcement

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.

Original languageEnglish
Pages (from-to)1999-2007
Number of pages9
JournalJournal of Sexual Medicine
Volume6
Issue number7
DOIs
StatePublished - Jul 10 2009
Externally publishedYes

Fingerprint

Peripheral Vascular Diseases
Erectile Dysfunction
Heart Failure
Mortality
Ankle Brachial Index
Reproductive Health
Cardiomyopathies
Angiotensin-Converting Enzyme Inhibitors

Keywords

  • Erectile Dysfunction
  • Heart Disease
  • Heart Failure
  • Mortality
  • Peripheral Vascular Disease

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients. / Hebert, Kathy; Lopez, Barbara; Macedo, Francisco Yuri Bulcao; Gomes, Conrado Rios; Urena, Johan; Arcement, Lee M.

In: Journal of Sexual Medicine, Vol. 6, No. 7, 10.07.2009, p. 1999-2007.

Research output: Contribution to journalArticle

Hebert, Kathy ; Lopez, Barbara ; Macedo, Francisco Yuri Bulcao ; Gomes, Conrado Rios ; Urena, Johan ; Arcement, Lee M. / Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients. In: Journal of Sexual Medicine. 2009 ; Vol. 6, No. 7. pp. 1999-2007.
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abstract = "Introduction. Seventy percent to 90{\%} of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40{\%}) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.",
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T1 - Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients

AU - Hebert, Kathy

AU - Lopez, Barbara

AU - Macedo, Francisco Yuri Bulcao

AU - Gomes, Conrado Rios

AU - Urena, Johan

AU - Arcement, Lee M.

PY - 2009/7/10

Y1 - 2009/7/10

N2 - Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.

AB - Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.

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KW - Heart Disease

KW - Heart Failure

KW - Mortality

KW - Peripheral Vascular Disease

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