Abstract
Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1999-2007 |
| Number of pages | 9 |
| Journal | Journal of Sexual Medicine |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 10 2009 |
| Externally published | Yes |
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Keywords
- Erectile Dysfunction
- Heart Disease
- Heart Failure
- Mortality
- Peripheral Vascular Disease
ASJC Scopus subject areas
- Urology
- Obstetrics and Gynecology
- Reproductive Medicine
Cite this
Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients. / Hebert, Kathy; Lopez, Barbara; Macedo, Francisco Yuri Bulcao; Gomes, Conrado Rios; Urena, Johan; Arcement, Lee M.
In: Journal of Sexual Medicine, Vol. 6, No. 7, 10.07.2009, p. 1999-2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients
AU - Hebert, Kathy
AU - Lopez, Barbara
AU - Macedo, Francisco Yuri Bulcao
AU - Gomes, Conrado Rios
AU - Urena, Johan
AU - Arcement, Lee M.
PY - 2009/7/10
Y1 - 2009/7/10
N2 - Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.
AB - Introduction. Seventy percent to 90% of patients with heart failure (HF) report erectile problems. There are no published data on whether erectile dysfunction (ED) and peripheral vascular disease (PVD) correlate with mortality in HF patients. Also, little is known regarding the impact of HF etiology on mortality in patients with ED. Aims. Our aim was to investigate the relationship between ED and mortality in HF patients, to evaluate whether the etiology of HF carries a prognostic measure in patients with ED, and to assess the impact of PVD on mortality in optimally treated HF patients with ED. Main Outcome Measures. The measures are: (i) mortality by presence or absence of ED; (ii) mortality by HF etiology and presence or absence of ED; and (iii) PVD and mortality in HF patients on optimal medical therapy with ED. Methods. This is a single-center, prospective cohort study of 328 male HF patients (ejection fraction≤40%) followed while being treated with optimal doses of beta blockers and angiotensin-converting enzyme inhibitors. The Sexual Health Inventory for Men survey was used to assess ED (no ED≥22 and ED≤21). Ankle brachial index (ABI) was used to assess PVD (normal ABI≥0.9 and abnormal ABI<0.9). Results. Kaplan-Meier curves were constructed to examine the relationship between the presence or absence of ED and PVD, and mortality in a HF population. Although not statistically significant, a trend for increased risk of death was demonstrated in the ischemic cardiomyopathy cohort with ED. Conclusions. ED, highly prevalent in this cohort, did not identify HF patients on optimal medical therapy at increased risk for mortality. Among the HF patients with ED, HF type was not associated with increased risk for mortality whereas PVD was independently associated with a statistically significant increase in mortality. Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J, and Arcement LM. Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients.
KW - Erectile Dysfunction
KW - Heart Disease
KW - Heart Failure
KW - Mortality
KW - Peripheral Vascular Disease
UR - http://www.scopus.com/inward/record.url?scp=67649863823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649863823&partnerID=8YFLogxK
U2 - 10.1111/j.1743-6109.2009.01278.x
DO - 10.1111/j.1743-6109.2009.01278.x
M3 - Article
C2 - 19453910
AN - SCOPUS:67649863823
VL - 6
SP - 1999
EP - 2007
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
SN - 1743-6095
IS - 7
ER -