Peripheral serotoninin Alzheimer's disease

Adarsh Kumar, S. Sevush, Mahendra Kumar, J. Ruiz, C. Eisdorfer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The platelet has been suggested to be a peripheral model of the central serotonergic neuron. This investigation was carried out in order to test the hypothesis that levels of serotonin (5-HT) in the platelet will be decreased in Alzheimer's disease (AD) since neurochemical studies suggest that levels of 5-HT are decreased in the brain of AD patients. We investigated platelet and plasma 5-HT in a group of AD patients (n = 22) as well as in age-matched normal control subjects (n = 20). The results show that the platelet level of 5-HT was significantly reduced in AD (65.7 ± 28.41 ng/108 platelets in AD vs. 112.9 ± 35.11 ng/108 platelets in controls; p = 0.0001). There was no effect on the levels of its metabolite 5-hydroxyindoleacetic acid. These findings suggest that the peripheral serotonergic system in AD is adversely affected.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuropsychobiology
Volume32
Issue number1
StatePublished - Jan 1 1995

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Alzheimer Disease
Blood Platelets
Serotonin
Serotonergic Neurons
Hydroxyindoleacetic Acid
Brain Diseases

Keywords

  • Alzheimer's disease
  • Platelet
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Kumar, A., Sevush, S., Kumar, M., Ruiz, J., & Eisdorfer, C. (1995). Peripheral serotoninin Alzheimer's disease. Neuropsychobiology, 32(1), 9-12.

Peripheral serotoninin Alzheimer's disease. / Kumar, Adarsh; Sevush, S.; Kumar, Mahendra; Ruiz, J.; Eisdorfer, C.

In: Neuropsychobiology, Vol. 32, No. 1, 01.01.1995, p. 9-12.

Research output: Contribution to journalArticle

Kumar, A, Sevush, S, Kumar, M, Ruiz, J & Eisdorfer, C 1995, 'Peripheral serotoninin Alzheimer's disease', Neuropsychobiology, vol. 32, no. 1, pp. 9-12.
Kumar A, Sevush S, Kumar M, Ruiz J, Eisdorfer C. Peripheral serotoninin Alzheimer's disease. Neuropsychobiology. 1995 Jan 1;32(1):9-12.
Kumar, Adarsh ; Sevush, S. ; Kumar, Mahendra ; Ruiz, J. ; Eisdorfer, C. / Peripheral serotoninin Alzheimer's disease. In: Neuropsychobiology. 1995 ; Vol. 32, No. 1. pp. 9-12.
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