Peripheral serotonin in alzheimer’s disease

Adarsh M. Kumar; Steven Sevush; Mahendra Kumar; Julio Ruiz; Carl Eisdorfer

doi:10.1159/000119205

Peripheral serotonin in alzheimer’s disease

Adarsh M. Kumar, Steven Sevush, Mahendra Kumar, Julio Ruiz, Carl Eisdorfer

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The platelet has been suggested to be a peripheral model of the central serotonergic neuron. This investigation was carried out in order to test the hypothesis that levels of serotonin (5-HT) in the platelet will be decreased in Alzheimer's disease (AD) since neurochemical studies suggest that levels of 5-HT are decreased in the brain of AD patients. We investigated platelet and plasma 5-HT in a group of AD patients (n = 22) as well as in age-matched normal control subjects (n = 20). The results show that the platelet level of 5-HT was significantly reduced in AD (65.7 ± 28.41 ng/10⁸ platelets in AD vs. 112.9 ± 35.11 ng/10⁸ platelets in controls; p = 0.0001). There was no effect on the levels of its metabolite 5-hydroxyindoleacetic acid. These findings suggest that the peripheral serotonergic system in AD is adversely affected.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Neuropsychobiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1159/000119205
State	Published - 1995
Externally published	Yes

Keywords

Alzheimer's disease
Platelet
Serotonin

ASJC Scopus subject areas

Psychiatry and Mental health
Neuroscience(all)
Psychology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000119205

Cite this

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AU - Sevush, Steven

AU - Kumar, Mahendra

AU - Ruiz, Julio

AU - Eisdorfer, Carl

PY - 1995

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Peripheral serotonin in alzheimer’s disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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