Peripheral serotonin in alzheimer’s disease

Adarsh M. Kumar, Steven Sevush, Mahendra Kumar, Julio Ruiz, Carl Eisdorfer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The platelet has been suggested to be a peripheral model of the central serotonergic neuron. This investigation was carried out in order to test the hypothesis that levels of serotonin (5-HT) in the platelet will be decreased in Alzheimer's disease (AD) since neurochemical studies suggest that levels of 5-HT are decreased in the brain of AD patients. We investigated platelet and plasma 5-HT in a group of AD patients (n = 22) as well as in age-matched normal control subjects (n = 20). The results show that the platelet level of 5-HT was significantly reduced in AD (65.7 ± 28.41 ng/108 platelets in AD vs. 112.9 ± 35.11 ng/108 platelets in controls; p = 0.0001). There was no effect on the levels of its metabolite 5-hydroxyindoleacetic acid. These findings suggest that the peripheral serotonergic system in AD is adversely affected.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
Issue number1
StatePublished - 1995
Externally publishedYes


  • Alzheimer's disease
  • Platelet
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)


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