Abstract
Purpose: To report wide-field fluorescein angiography findings in the peripheral retina of eyes with childhood glaucoma. Methods: Fluorescein angiograms were examined retrospectively in 12 patients with childhood glaucoma who underwent wide-field fluorescein angiography after surgical or medical treatment of glaucoma. This series included 12 eyes of 6 patients with primary congenital glaucoma, 5 eyes of 3 patients with glaucoma associated with congenital cataract surgery, 4 eyes of 2 patients with glaucoma associated with a systemic condition, and 1 eye of 1 patient with phakomatosis pigmentovascularis Type II. RetCam fundus photography images and digital fluorescein angiography were performed under general anesthesia. Results: The most common finding observed in our series was peripheral retinal nonperfusion, which affected 20 eyes (91%). Other notable features seen were circumferential branching of the retinal vessels parallel to the ora serrata (77%), venous shunts (50%), and abnormal capillary branching patterns, including capillary dilatation (41%) and tortuous capillary tangles (18%). Leakage at the junction of vascular and avascular retina was not commonly seen (13.6%). None of the eyes had evidence of retinal neovascularization or fibrovascular proliferation. Conclusion: Retinal vascular abnormalities and peripheral nonperfusion are novel findings in childhood glaucoma. Further studies are needed to understand the significance and possible long-term consequences of these findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1028-1035 |
| Number of pages | 8 |
| Journal | Retina |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 8 2015 |
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Keywords
- childhood glaucoma
- peripheral retinal vascular nonperfusion
- retinal vascular abnormalities
ASJC Scopus subject areas
- Ophthalmology
Cite this
Peripheral retinal vasculopathy in childhood glaucoma. / Kim, Hanna Y.; Hodapp, Elizabeth; Grajewski, Alana Lee; Sarraf, David; John, Vishak J.; Hess, Ditte J.; Berrocal, Audina.
In: Retina, Vol. 35, No. 5, 08.05.2015, p. 1028-1035.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral retinal vasculopathy in childhood glaucoma
AU - Kim, Hanna Y.
AU - Hodapp, Elizabeth
AU - Grajewski, Alana Lee
AU - Sarraf, David
AU - John, Vishak J.
AU - Hess, Ditte J.
AU - Berrocal, Audina
PY - 2015/5/8
Y1 - 2015/5/8
N2 - Purpose: To report wide-field fluorescein angiography findings in the peripheral retina of eyes with childhood glaucoma. Methods: Fluorescein angiograms were examined retrospectively in 12 patients with childhood glaucoma who underwent wide-field fluorescein angiography after surgical or medical treatment of glaucoma. This series included 12 eyes of 6 patients with primary congenital glaucoma, 5 eyes of 3 patients with glaucoma associated with congenital cataract surgery, 4 eyes of 2 patients with glaucoma associated with a systemic condition, and 1 eye of 1 patient with phakomatosis pigmentovascularis Type II. RetCam fundus photography images and digital fluorescein angiography were performed under general anesthesia. Results: The most common finding observed in our series was peripheral retinal nonperfusion, which affected 20 eyes (91%). Other notable features seen were circumferential branching of the retinal vessels parallel to the ora serrata (77%), venous shunts (50%), and abnormal capillary branching patterns, including capillary dilatation (41%) and tortuous capillary tangles (18%). Leakage at the junction of vascular and avascular retina was not commonly seen (13.6%). None of the eyes had evidence of retinal neovascularization or fibrovascular proliferation. Conclusion: Retinal vascular abnormalities and peripheral nonperfusion are novel findings in childhood glaucoma. Further studies are needed to understand the significance and possible long-term consequences of these findings.
AB - Purpose: To report wide-field fluorescein angiography findings in the peripheral retina of eyes with childhood glaucoma. Methods: Fluorescein angiograms were examined retrospectively in 12 patients with childhood glaucoma who underwent wide-field fluorescein angiography after surgical or medical treatment of glaucoma. This series included 12 eyes of 6 patients with primary congenital glaucoma, 5 eyes of 3 patients with glaucoma associated with congenital cataract surgery, 4 eyes of 2 patients with glaucoma associated with a systemic condition, and 1 eye of 1 patient with phakomatosis pigmentovascularis Type II. RetCam fundus photography images and digital fluorescein angiography were performed under general anesthesia. Results: The most common finding observed in our series was peripheral retinal nonperfusion, which affected 20 eyes (91%). Other notable features seen were circumferential branching of the retinal vessels parallel to the ora serrata (77%), venous shunts (50%), and abnormal capillary branching patterns, including capillary dilatation (41%) and tortuous capillary tangles (18%). Leakage at the junction of vascular and avascular retina was not commonly seen (13.6%). None of the eyes had evidence of retinal neovascularization or fibrovascular proliferation. Conclusion: Retinal vascular abnormalities and peripheral nonperfusion are novel findings in childhood glaucoma. Further studies are needed to understand the significance and possible long-term consequences of these findings.
KW - childhood glaucoma
KW - peripheral retinal vascular nonperfusion
KW - retinal vascular abnormalities
UR - http://www.scopus.com/inward/record.url?scp=84929001392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929001392&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000000415
DO - 10.1097/IAE.0000000000000415
M3 - Article
C2 - 25545481
AN - SCOPUS:84929001392
VL - 35
SP - 1028
EP - 1035
JO - Retina
JF - Retina
SN - 0275-004X
IS - 5
ER -