Peripheral retinal vasculopathy in childhood glaucoma

Hanna Y. Kim, Elizabeth A. Hodapp, Alana L. Grajewski, David Sarraf, Vishak J. John, Ditte J. Hess, Audina M. Berrocal

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: To report wide-field fluorescein angiography findings in the peripheral retina of eyes with childhood glaucoma. Methods: Fluorescein angiograms were examined retrospectively in 12 patients with childhood glaucoma who underwent wide-field fluorescein angiography after surgical or medical treatment of glaucoma. This series included 12 eyes of 6 patients with primary congenital glaucoma, 5 eyes of 3 patients with glaucoma associated with congenital cataract surgery, 4 eyes of 2 patients with glaucoma associated with a systemic condition, and 1 eye of 1 patient with phakomatosis pigmentovascularis Type II. RetCam fundus photography images and digital fluorescein angiography were performed under general anesthesia. Results: The most common finding observed in our series was peripheral retinal nonperfusion, which affected 20 eyes (91%). Other notable features seen were circumferential branching of the retinal vessels parallel to the ora serrata (77%), venous shunts (50%), and abnormal capillary branching patterns, including capillary dilatation (41%) and tortuous capillary tangles (18%). Leakage at the junction of vascular and avascular retina was not commonly seen (13.6%). None of the eyes had evidence of retinal neovascularization or fibrovascular proliferation. Conclusion: Retinal vascular abnormalities and peripheral nonperfusion are novel findings in childhood glaucoma. Further studies are needed to understand the significance and possible long-term consequences of these findings.

Original languageEnglish (US)
Pages (from-to)1028-1035
Number of pages8
JournalRetina
Volume35
Issue number5
DOIs
StatePublished - May 8 2015

Keywords

  • childhood glaucoma
  • peripheral retinal vascular nonperfusion
  • retinal vascular abnormalities

ASJC Scopus subject areas

  • Ophthalmology

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    Kim, H. Y., Hodapp, E. A., Grajewski, A. L., Sarraf, D., John, V. J., Hess, D. J., & Berrocal, A. M. (2015). Peripheral retinal vasculopathy in childhood glaucoma. Retina, 35(5), 1028-1035. https://doi.org/10.1097/IAE.0000000000000415