Peripheral Reticular Pigmentary Change Is Associated with Complement Factor H Polymorphism (Y402H) in Age-Related Macular Degeneration

R. Keith Shuler, Silke Schmidt, Paul Gallins, Michael A. Hauser, William K. Scott, Jennifer Caldwell, Anita Agarwal, Jonathan L. Haines, Margaret A. Pericak-Vance, Eric A. Postel

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objective: To examine phenotypes of age-related macular degeneration (AMD) patients with the complement factor H (CFH) variant (Y402H, C allele at rs1061170). Design: Clinic-based case series study. Participants: The data set contained a total of 956 unrelated cases of AMD. Methods: Age-related macular degeneration phenotypes of 796 carriers of the CFH Y402H variant were compared with the AMD phenotypes of 160 noncarriers. Main Outcome Measures: Presence or absence of 34 phenotypic features. Results: Of the 34 features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant (P = 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose-response fashion. Conclusions: The CFH Y402H polymorphism is associated with PRPC, suggesting that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula and should consider incorporating peripheral retinal changes. Phenotypes that suggest a high-risk genotype may prove valuable for diagnostic, therapeutic, and research purposes.

Original languageEnglish (US)
Pages (from-to)520-524
Number of pages5
JournalOphthalmology
Volume115
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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