Peripheral nerve vasculitis: Immune characterization of the vascular lesions

J. T. Kissel, J. L. Riethman, J. Omerza, Kottil W Rammohan, J. R. Mendell

Research output: Contribution to journalArticle

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Abstract

Quantitative immunohistochemical analyses were performed on 22 nerve biopsy specimens from patients with systemic vasculitis (n = 14) or isolated vasculitis of peripheral nerve (n = 8). In the vascular lesions the cellular infiltrates were composed primarily of T cells (71 ± 18%; mean ± SD) and macrophages (27 ± 17%), and the majority of the T cells (65 ± 20%) were cytotoxic/suppressor CD8 cells. B cells were seen in only 4 cases and constituted less than 2% of all cells. Natural killer cells and polymorphonuclear leukocytes were rare, and a leukocytoclastic response was not observed. Fourteen biopsy specimens had vascular deposits of immunoglobulins G and M and complement components C3 and C5b-9 membrane attack complex, while 4 had only the latter. The fact that the immunoglobulin and complement deposits were seen only in vessels that had corresponding intense cellular infiltrates suggests an important, but perhaps not primary, role for immune complexes in causing the vascular lesions. Statistical analysis revealed striking similarities in the lesions of patients with isolated nerve vasculitis and those with systemic vasculitides, suggesting a common pathogenic mechanism. Collectively, our observations suggest an important role for a T-cell-dependent cell-mediated process as a primary mechanism of vessel injury in peripheral nerve vasculitis.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalAnnals of Neurology
Volume25
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

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Vasculitis
Peripheral Nerves
Complement Membrane Attack Complex
Blood Vessels
Systemic Vasculitis
T-Lymphocytes
Complement C5b
Biopsy
Myeloma Proteins
Peripheral Nerve Injuries
Complement C3
Antigen-Antibody Complex
Natural Killer Cells
Immunoglobulin M
Immunoglobulins
Neutrophils
B-Lymphocytes
Immunoglobulin G
Macrophages

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kissel, J. T., Riethman, J. L., Omerza, J., Rammohan, K. W., & Mendell, J. R. (1989). Peripheral nerve vasculitis: Immune characterization of the vascular lesions. Annals of Neurology, 25(3), 291-297.

Peripheral nerve vasculitis : Immune characterization of the vascular lesions. / Kissel, J. T.; Riethman, J. L.; Omerza, J.; Rammohan, Kottil W; Mendell, J. R.

In: Annals of Neurology, Vol. 25, No. 3, 01.01.1989, p. 291-297.

Research output: Contribution to journalArticle

Kissel, JT, Riethman, JL, Omerza, J, Rammohan, KW & Mendell, JR 1989, 'Peripheral nerve vasculitis: Immune characterization of the vascular lesions', Annals of Neurology, vol. 25, no. 3, pp. 291-297.
Kissel JT, Riethman JL, Omerza J, Rammohan KW, Mendell JR. Peripheral nerve vasculitis: Immune characterization of the vascular lesions. Annals of Neurology. 1989 Jan 1;25(3):291-297.
Kissel, J. T. ; Riethman, J. L. ; Omerza, J. ; Rammohan, Kottil W ; Mendell, J. R. / Peripheral nerve vasculitis : Immune characterization of the vascular lesions. In: Annals of Neurology. 1989 ; Vol. 25, No. 3. pp. 291-297.
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