Peripheral defocus of the monkey crystalline lens with accommodation in a lens stretcher

Bianca Maceo Heilman, Fabrice Manns, Marco Ruggeri, Arthur Ho, Alex Gonzalez, Cor Rowaan, Andres Bernal, Esdras Arrieta, Jean Marie Parel

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

PURPOSE. To characterize the peripheral defocus of the monkey crystalline lens and its changes with accommodation. METHODS. Experiments were performed on 15 lenses from 11 cynomolgus monkey eyes (age: 3.8–12.4 years, postmortem time: 33.5 ± 15.3 hours). The tissue was mounted in a motorized lens stretcher to allow for measurements of the lens in the accommodated (unstretched) and unaccommodated (stretched) states. A custom-built combined laser ray tracing and optical coherence tomography system was used to measure the paraxial on-axis and off-axis lens power for delivery angles ranging from -20° to +20° (in air). For each delivery angle, peripheral defocus was quantified as the difference between paraxial off-axis and on-axis power. The peripheral defocus of the lens was compared in the unstretched and stretched states. RESULTS. On average, the paraxial on-axis lens power was 52.0 ± 3.4 D in the unstretched state and 32.5 ± 5.1 D in the stretched state. In both states, the lens power increased with increasing delivery angle. From 0° to +20°, the relative peripheral lens power increased by 10.7 ± 1.4 D in the unstretched state and 7.5 ± 1.6 D in the stretched state. The change in field curvature with accommodation was statistically significant (P < 0.001), indicating that the unstretched (accommodated) lens has greater curvature or relative peripheral power. CONCLUSIONS. The cynomolgus monkey lens has significant accommodation-dependent curvature of field, which suggests that the lens asserts a significant contribution to the peripheral optical performance of the eye that also varies with the state of accommodation.

Original languageEnglish (US)
Pages (from-to)2177-2186
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume59
Issue number5
DOIs
StatePublished - Apr 2018

Keywords

  • Accommodation
  • Crystalline lens
  • Laser ray tracing
  • Peripheral defocus

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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