Peripheral antigen-expressing cells in type 1 diabetes

Kamalaveni R. Prabakar, Alberto Pugliese

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Studies in both humans and rodent models provide new insight into key mechanisms regulating tolerance to self-molecules. There is evidence that tissue-specific molecules are expressed in the thymus and peripheral lymphoid tissues (PLTs) by specialized antigen-presenting cells (APCs), and that such expression is critical for self-tolerance. Insulin, a key hormone exclusively produced by pancreatic β cells and a critical autoantigen in type 1 diabetes, provides an excellent example of a molecule with tissue-restricted expression that is ectopically expressed by APCs in both thymus and PLTs. APCs may play a role in insulin presentation in both the central and peripheral immune system. Functional data from several transgenic and knockout mouse models, some specific for the expression of insulin, help dissect the significance of self-molecule presentation by APCs and its role in autoimmune diabetes.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalCurrent diabetes reports
Volume4
Issue number2
DOIs
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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