Peripheral antigen-expressing cells in type 1 diabetes

Kamalaveni R. Prabakar, Alberto Pugliese

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Studies in both humans and rodent models provide new insight into key mechanisms regulating tolerance to self-molecules. There is evidence that tissue-specific molecules are expressed in the thymus and peripheral lymphoid tissues (PLTs) by specialized antigen-presenting cells (APCs), and that such expression is critical for self-tolerance. Insulin, a key hormone exclusively produced by pancreatic β cells and a critical autoantigen in type 1 diabetes, provides an excellent example of a molecule with tissue-restricted expression that is ectopically expressed by APCs in both thymus and PLTs. APCs may play a role in insulin presentation in both the central and peripheral immune system. Functional data from several transgenic and knockout mouse models, some specific for the expression of insulin, help dissect the significance of self-molecule presentation by APCs and its role in autoimmune diabetes.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalCurrent Diabetes Reports
Volume4
Issue number2
StatePublished - Apr 1 2004

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Antigen-Presenting Cells
Type 1 Diabetes Mellitus
Antigens
Lymphoid Tissue
Insulin
Thymus Gland
Self Tolerance
Autoantigens
Knockout Mice
Transgenic Mice
Immune System
Rodentia
Hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Peripheral antigen-expressing cells in type 1 diabetes. / Prabakar, Kamalaveni R.; Pugliese, Alberto.

In: Current Diabetes Reports, Vol. 4, No. 2, 01.04.2004, p. 101-107.

Research output: Contribution to journalArticle

Prabakar, Kamalaveni R. ; Pugliese, Alberto. / Peripheral antigen-expressing cells in type 1 diabetes. In: Current Diabetes Reports. 2004 ; Vol. 4, No. 2. pp. 101-107.
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