Peripheral antigen-expressing cells and autoimmunity

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

There is growing evidence that self-molecules with tissue-restricted expression are also expressed at low levels in the thymus, where such expression may affect the development of self-tolerance. Genetic factors may modulate such expression and, in turn, influence susceptibility to autoimmune responses against specific molecules. Contrasting reports exist regarding the phenotype of the cells that express self-molecules in the thymus. Indeed, both bone marrow derived antigen-presenting cells and thymic epithelial cells were reported to express self-molecules with tissue-restricted expression. Further studies of these cells and the mechanisms by which they exert their putative tolerogenic effects clearly are necessary.

Original languageEnglish (US)
Pages (from-to)411-430
Number of pages20
JournalEndocrinology and Metabolism Clinics of North America
Volume31
Issue number2
DOIs
StatePublished - Jul 4 2002

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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