There is growing evidence that self-molecules with tissue-restricted expression are also expressed at low levels in the thymus, where such expression may affect the development of self-tolerance. Genetic factors may modulate such expression and, in turn, influence susceptibility to autoimmune responses against specific molecules. Contrasting reports exist regarding the phenotype of the cells that express self-molecules in the thymus. Indeed, both bone marrow derived antigen-presenting cells and thymic epithelial cells were reported to express self-molecules with tissue-restricted expression. Further studies of these cells and the mechanisms by which they exert their putative tolerogenic effects clearly are necessary.
|Original language||English (US)|
|Number of pages||20|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Jul 4 2002|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism