Peripheral anterior chamber depth and screening techniques for primary angle closure disease in community elderly Chinese

Qin Luo, Wenwen Xue, Yin Yuan, Chaowei Fu, Jiangnan He, Haidong Zou, Xiaowei Tong, Richard K. Lee, Ling Ge

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: To investigate the distribution of peripheral anterior chamber depth (ACD) and the relationship between peripheral ACD and gonioscopy compared to other ocular parameters for primary angle closure disease (PACD) screening. We performed a population-based survey in Pudong New District of Shanghai, China, in 2011. Methods: Cross-sectional study. Adults 50 and older were enrolled from a population-based study using cluster random sampling in Pudong New District, Shanghai. Remote ocular screening was performed with digital anterior eye structure photography. Van Herrick measurements were used to evaluate the peripheral ACD, the depth of the peripheral anterior chamber, and corneal thickness (CT), and the ACD to CT ratio was calculated. Subjects with peripheral ACD less than 0.5 CT were made follow-up appointments for clinical examination with gonioscopy. Receiver operating characteristic curves (ROC) were generated to show the performance of different tests in screening for primary angle closure disease (PACD). Results: Two thousand five hundred twenty-eight adults participated in the study with 91 patients diagnosed with PACD. Two thousand four hundred sixty-three subjects had valid data in the right eye available for analysis. The mean peripheral ACD values for men and women were significantly different: 1.04 ± 0.46 (range 0.11-2.93) CT and 0.87 ± 0.41 (range 0.12-2.96) CT respectively (t = - 4.18; P<0.0001). Multivariate logistic regression analysis reveals that peripheral ACD declined by 0.31 CT (P < 0.0001) per diopter of SE and was 0.19 CT (P < 0.0001) shallower in women than in men (r2 = 0.1304, P < 0.0001). Peripheral ACD performed best in screening for PACD. Conclusions: Peripheral ACD measurement is recommended for PACD screening in community elderly Chinese.

Original languageEnglish (US)
Article number353
JournalBMC ophthalmology
Issue number1
StatePublished - Aug 28 2020
Externally publishedYes


  • Chinese
  • Peripheral anterior chamber depth
  • Primary angle closure disease
  • Screening

ASJC Scopus subject areas

  • Ophthalmology


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