Peripheral administration of hypothalamic peptides results in CNS changes

Abba J. Kastin, David H. Coy, Andrew V Schally, Lyle H. Miller

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

CNS effects have been demonstrated for many peptides initially isolated for other purposes from hypothalamic tissue. These effects do not require the mediation of the pituitary or other endocrine organs and, therefore, can be loosely considered as "extra-endocrine". Although found in locations of the brain inside the blood-brain barrier, peptides can exert significant alterations in the CNS after peripheral injections. The CNS changes persist long after most of the peptide has left the blood stream. In many cases results of studies performed with these peptides in laboratory animals have been extended to clinical investigations. Already there are indications of beneficial effects of peptides found in the hypothalamus in such disorders as parkinsonism, mental depression, and mental retardation. It is reasonable to anticipate that other neurological and mental disorders may be alleviated and performance optimized by brain peptides.

Original languageEnglish
Pages (from-to)293-312
Number of pages20
JournalPharmacological Research Communications
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Peptides
Brain
Laboratory Animals
Parkinsonian Disorders
Nervous System Diseases
Blood-Brain Barrier
Mental Disorders
Intellectual Disability
Hypothalamus
Depression
Injections

ASJC Scopus subject areas

  • Pharmacology

Cite this

Peripheral administration of hypothalamic peptides results in CNS changes. / Kastin, Abba J.; Coy, David H.; Schally, Andrew V; Miller, Lyle H.

In: Pharmacological Research Communications, Vol. 10, No. 4, 01.01.1978, p. 293-312.

Research output: Contribution to journalArticle

Kastin, Abba J. ; Coy, David H. ; Schally, Andrew V ; Miller, Lyle H. / Peripheral administration of hypothalamic peptides results in CNS changes. In: Pharmacological Research Communications. 1978 ; Vol. 10, No. 4. pp. 293-312.
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