Peripapillary and macular choroidal thickness in glaucoma

Hamid Hosseini, Naveed Nilforushan, Sasan Moghimi, Elena Bitrian, Jay Riddle, Gina Yoo Lee, Joseph Caprioli, Kouros Nouri-Mahdavi

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Purpose: To compare choroidal thickness (CT) between individuals with and without glaucomatous damage and to explore the association of peripapillary and submacular CT with glaucoma severity using spectral domain optical coherence tomography (SD-OCT). Methods: Ninety-one eyes of 20 normal subjects and 43 glaucoma patients from the UCLA SD-OCT Imaging Study were enrolled. Imaging was performed using Cirrus HD-OCT. Choroidal thickness was measured at four predetermined points in the macular and peripapillary regions, and compared between glaucoma and control groups before and after adjusting for potential confounding variables. Results: The average (± standard deviation) mean deviation (MD) on visual fields was -0.3 (±2.0) dB in controls and -3.5 (±3.5) dB in glaucoma patients. Age, axial length and their interaction were the most significant factors affecting CT on multivariate analysis. Adjusted average CT (corrected for age, axial length, their interaction, gender and lens status) however, was not different between glaucoma patients and the control group (P=0.083) except in the temporal parafoveal region (P=0.037); nor was choroidal thickness related to glaucoma severity (r=-0.187, P=0.176 for correlation with MD, r=-0.151, P=0.275 for correlation with average nerve fiber layer thickness). Conclusions: Choroidal thickness of the macular and peripapillary regions is not decreased in glaucoma. Anatomical measurements with SD-OCT do not support the possible influence of the choroid on the pathophysiology of glaucoma.

Original languageEnglish (US)
Pages (from-to)154-161
Number of pages8
JournalJournal of Ophthalmic and Vision Research
Issue number2
StatePublished - 2014
Externally publishedYes


  • Choroidal thickness
  • Glaucoma
  • Macula
  • Peripapillary
  • Spectral-domain optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology


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