Periostin, an Emerging Player in Itch Sensation

Takashi Hashimoto, Santosh K. Mishra, Thierry Olivry, Gil Yosipovitch

Research output: Contribution to journalReview articlepeer-review


Periostin, an extracellular matrix and matricellular protein, binds to several types of integrins that transduce its signals. Its function in allergic inflammation is the establishment of sustained chronic inflammation through an amplification of T helper type 2‒immune responses. In addition, recent studies have shown a significant role of periostin in itch sensation through direct integrin-mediated stimulation of nerve fibers and interaction with immune and nonimmune cells (e.g., macrophages, eosinophils, basophils, and keratinocytes). The objective of this review is to describe the role of periostin in itch induction in human and animal models and its expression in human pruritic conditions.

Original languageEnglish (US)
JournalJournal of Investigative Dermatology
StateAccepted/In press - 2021
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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