Perioral granulomatous dermatitis: Two cases treated with clarithromycin

C. Vincenzi, G. Parente, A. Tosti

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


BACKGROUND: Two young patients with numerous flesh-coloured micropapular lesions involving the perioral and perinasal areas presented to us. In both cases the facial eruption had appeared during application of topical corticosteroids for a mild seborrhoeic dermatitis of the face. Histopathological examination revealed a sarcoid-like granulomatous reaction leading to a granulomatous perioral dermatitis. METHODS: We treated the first patient initially with minocycline 100 mg/day, but after 1 month and no improvement treatment with oral clarithromycin 250 mg/day was commenced for 6 weeks and then 125 mg/day for a further 2 months. The second patient began treatment with doxycycline 100 mg/day for 50 days and was then transferred to clarithromycin 250 mg/day for 10 days and then 250 mg on alternate days for 20 further days. RESULTS: In both patients, treatment with oral clarithromycin led to complete clearance of the facial eruptions. CONCLUSION: Clarithromycin is considered to be a useful alternative to tetracycline in the treatment of perioral granulomatous dermatitis.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalJournal of Dermatological Treatment
Issue number1
StatePublished - 2000
Externally publishedYes


  • Clarithromycin
  • Perioral granulomatous dermatitis
  • Sarcoid-like granuloma
  • Tetracycline
  • Topical corticosteroids

ASJC Scopus subject areas

  • Dermatology


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