Periodontal bacteria and hypertension: The oral infections and vascular disease epidemiology study (INVEST)

Moïse Desvarieux, Ryan T. Demmer, David R. Jacobs, Tatjana Rundek, Bernadette Boden-Albala, Ralph L Sacco, Panos N. Papapanou

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objective: Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension. METHODS AND Results: Six hundred and fifty-three dentate men and women with no history of stroke or myocardial infarction were enrolled in INVEST. We collected 4533 subgingival plaque samples (average of seven samples per participant). These were quantitatively assessed for 11 periodontal bacteria using DNA-DNA checkerboard hybridization. Cardiovascular risk factor measurements were obtained. Blood pressure and hypertension (SBP â‰1 140 mmHg, DBP â‰1 90 mmHg or taking antihypertensive medication, or self-reported history) were each regressed on the level of bacteria: considered causative of periodontal disease (etiologic bacterial burden); associated with periodontal disease (putative bacterial burden); and associated with periodontal health (health-associated bacterial burden). All analyses were adjusted for age, race/ethnicity, sex, education, BMI, smoking, diabetes, low-density lipoprotein and high-density lipoprotein cholesterol. Etiologic bacterial burden was positively associated with both blood pressure and prevalent hypertension. Comparing the highest and lowest tertiles of etiologic bacterial burden, SBP was 9 mmHg higher, DBP was 5 mmHg higher (P for linear trend was less than 0.001 in each case), and the odds ratio for prevalent hypertension was 3.05 (95% confidence interval 1.60-5.82) after multivariable adjustment. Conclusion: Our data provide evidence of a direct relationship between the levels of subgingival periodontal bacteria and both SBP and DBP as well as hypertension prevalence.

Original languageEnglish
Pages (from-to)1413-1421
Number of pages9
JournalJournal of Hypertension
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2010

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Mouth Diseases
Vascular Diseases
Epidemiology
Hypertension
Bacteria
Infection
Periodontal Diseases
Blood Pressure
Social Adjustment
Sex Education
Microbiota
DNA
Health
LDL Lipoproteins
HDL Cholesterol
Antihypertensive Agents
Cardiovascular Diseases
Smoking
History
Stroke

Keywords

  • blood pressure
  • epidemiology
  • hypertension
  • infection
  • inflammation
  • periodontitis

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Periodontal bacteria and hypertension : The oral infections and vascular disease epidemiology study (INVEST). / Desvarieux, Moïse; Demmer, Ryan T.; Jacobs, David R.; Rundek, Tatjana; Boden-Albala, Bernadette; Sacco, Ralph L; Papapanou, Panos N.

In: Journal of Hypertension, Vol. 28, No. 7, 01.07.2010, p. 1413-1421.

Research output: Contribution to journalArticle

Desvarieux, Moïse ; Demmer, Ryan T. ; Jacobs, David R. ; Rundek, Tatjana ; Boden-Albala, Bernadette ; Sacco, Ralph L ; Papapanou, Panos N. / Periodontal bacteria and hypertension : The oral infections and vascular disease epidemiology study (INVEST). In: Journal of Hypertension. 2010 ; Vol. 28, No. 7. pp. 1413-1421.
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