Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek; David H. Reese; Hilda K. Lo; Theodore I. Malinin; George I. Malinin

doi:10.1016/0006-291X(88)90182-9

Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek, David H. Reese, Hilda K. Lo, Theodore I. Malinin, George I. Malinin

Orthopaedics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

Original language	English (US)
Pages (from-to)	606-612
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(88)90182-9
State	Published - Jul 29 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(88)90182-9

Fingerprint Dive into the research topics of 'Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover'. Together they form a unique fingerprint.

Cite this

@article{631e979d41ac471fb16f3b162a287bc0,

title = "Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover",

abstract = "The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.",

author = "Hornicek, {Francis J.} and Reese, {David H.} and Lo, {Hilda K.} and Malinin, {Theodore I.} and Malinin, {George I.}",

year = "1988",

month = jul,

day = "29",

doi = "10.1016/0006-291X(88)90182-9",

language = "English (US)",

volume = "154",

pages = "606--612",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

AU - Hornicek, Francis J.

AU - Reese, David H.

AU - Lo, Hilda K.

AU - Malinin, Theodore I.

AU - Malinin, George I.

PY - 1988/7/29

Y1 - 1988/7/29

N2 - The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

AB - The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

UR - http://www.scopus.com/inward/record.url?scp=0023755454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023755454&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(88)90182-9

DO - 10.1016/0006-291X(88)90182-9

M3 - Article

C2 - 2840902

AN - SCOPUS:0023755454

VL - 154

SP - 606

EP - 612

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -