Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek; David H. Reese; Hilda K. Lo; Theodore Malinin; George I. Malinin

doi:10.1016/0006-291X(88)90182-9

Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek, David H. Reese, Hilda K. Lo, Theodore Malinin, George I. Malinin

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Research output: Contribution to journal › Article

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Abstract

The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

Original language	English
Pages (from-to)	606-612
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(88)90182-9
State	Published - Jul 29 1988

Fingerprint

Periodic Acid

Lymphocytes

Lymphocyte Activation

Phosphatidylinositols

Mitogens

Cell culture

Lectins

Nucleic Acids

Interleukin-2

Oxidation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Hornicek, F. J., Reese, D. H., Lo, H. K., Malinin, T., & Malinin, G. I. (1988). Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover. Biochemical and Biophysical Research Communications, 154(2), 606-612. https://doi.org/10.1016/0006-291X(88)90182-9

Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover. / Hornicek, Francis J.; Reese, David H.; Lo, Hilda K.; Malinin, Theodore; Malinin, George I.

In: Biochemical and Biophysical Research Communications, Vol. 154, No. 2, 29.07.1988, p. 606-612.

Research output: Contribution to journal › Article

Hornicek, FJ, Reese, DH, Lo, HK, Malinin, T & Malinin, GI 1988, 'Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover', Biochemical and Biophysical Research Communications, vol. 154, no. 2, pp. 606-612. https://doi.org/10.1016/0006-291X(88)90182-9

Hornicek FJ, Reese DH, Lo HK, Malinin T, Malinin GI. Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover. Biochemical and Biophysical Research Communications. 1988 Jul 29;154(2):606-612. https://doi.org/10.1016/0006-291X(88)90182-9

Hornicek, Francis J. ; Reese, David H. ; Lo, Hilda K. ; Malinin, Theodore ; Malinin, George I. / Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 154, No. 2. pp. 606-612.

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10.1016/0006-291X(88)90182-9