Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek, David H. Reese, Hilda K. Lo, Theodore I. Malinin, George I. Malinin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

Original languageEnglish (US)
Pages (from-to)606-612
Number of pages7
JournalBiochemical and biophysical research communications
Volume154
Issue number2
DOIs
StatePublished - Jul 29 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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