Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek; David H. Reese; Hilda K. Lo; Theodore I. Malinin; George I. Malinin

doi:10.1016/0006-291X(88)90182-9

Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Francis J. Hornicek, David H. Reese, Hilda K. Lo, Theodore I. Malinin, George I. Malinin

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Abstract

The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

Original language	English (US)
Pages (from-to)	606-612
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	154
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(88)90182-9
State	Published - Jul 29 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.",

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AU - Reese, David H.

AU - Lo, Hilda K.

AU - Malinin, Theodore I.

AU - Malinin, George I.

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N2 - The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

AB - The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.

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Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover

Abstract

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