Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients

Laura C. Gioia, Mahesh Kate, Rebecca Mccourt, Bronwen Gould, Shelagh B. Coutts, Dariush Dowlatshahi, Negar Asdaghi, Thomas Jeerakathil, Michael D. Hill, Andrew M. Demchuk, Brian Buck, Derek Emery, Ashfaq Shuaib, Kenneth Butcher

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Statin therapy has been associated with improved cerebral blood flow (CBF) and decreased perihematoma edema in animal models of intracerebral hemorrhage (ICH). We aimed to assess the relationship between statin use and cerebral hemodynamics in ICH patients. A post hoc analysis of 73 ICH patients enrolled in the Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial (ICH ADAPT). Patients presenting <24 hours from ICH onset were randomized to a systolic blood pressure target <150 or <180 mm Hg with computed tomography perfusion imaging 2 hours after randomization. Cerebral blood flow maps were calculated. Hematoma and edema volumes were measured planimetrically. Regression models were used to assess the relationship between statin use, perihematoma edema and cerebral hemodynamics. Fourteen patients (19%) were taking statins at the time of ICH. Statin-treated patients had similar median (IQR Q25 to 75) hematoma volumes (21.1 (9.5 to 38.3) mL versus 14.5 (5.6 to 27.7) mL, P=0.25), but larger median (IQR Q25 to 75) perihematoma edema volumes (2.9 (1.7 to 9.0) mL versus 2.2 (0.8 to 3.5) mL, P=0.02) compared with nontreated patients. Perihematoma and ipsilateral hemispheric CBF were similar in both groups. A multivariate linear regression model revealed that statin use and hematoma volumes were independent predictors of acute edema volumes. Statin use does not affect CBF in ICH patients. Statin use, along with hematoma volume, are independently associated with increased perihematoma edema volume.

Original languageEnglish (US)
Pages (from-to)1175-1180
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes


  • intracerebral hemorrhage
  • perfusion imaging
  • perihematoma edema
  • statins

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Perihematoma cerebral blood flow is unaffected by statin use in acute intracerebral hemorrhage patients'. Together they form a unique fingerprint.

Cite this