Performance evaluation of automated segmentation software on optical coherence tomography volume data

Jing Tian, Boglarka Varga, Erika Tatrai, Palya Fanni, Gabor Mark Somfai, William E. Smiddy, Delia Cabrera Debuc

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Over the past two decades a significant number of OCT segmentation approaches have been proposed in the literature. Each methodology has been conceived for and/or evaluated using specific datasets that do not reflect the complexities of the majority of widely available retinal features observed in clinical settings. In addition, there does not exist an appropriate OCT dataset with ground truth that reflects the realities of everyday retinal features observed in clinical settings. While the need for unbiased performance evaluation of automated segmentation algorithms is obvious, the validation process of segmentation algorithms have been usually performed by comparing with manual labelings from each study and there has been a lack of common ground truth. Therefore, a performance comparison of different algorithms using the same ground truth has never been performed. This paper reviews research-oriented tools for automated segmentation of the retinal tissue on OCT images. It also evaluates and compares the performance of these software tools with a common ground truth.

Original languageEnglish (US)
Pages (from-to)478-489
Number of pages12
JournalJournal of Biophotonics
Issue number5
StatePublished - May 1 2016


  • Automated segmentation software
  • Ground truth
  • Optical coherence tomography
  • Performance evaluation
  • Spectralis SD-OCT

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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