TY - JOUR
T1 - Performance-based assessment of functional skills in severe mental illness
T2 - Results of a large-scale study in China
AU - McIntosh, Belinda J.
AU - Zhang, Xiang Yang
AU - Kosten, Thomas
AU - Tan, Shu Ping
AU - Xiu, Mei Hong
AU - Rakofsky, Jeffrey
AU - Harvey, Philip D.
N1 - Funding Information:
Dr. Harvey had a research grant from Astra-Zeneca Pharmaceuticals . He has served as consultant to Abbott Labs, Bristol–Myers–Squibb, Cypress Bioscience, En Vivo Pharma, Genentech, Merck and Company, Sunovion, Shire Pharma, and Teva Pharma.
Funding Information:
This research was supported by NIMH Grants K05-DA0454, P50-DA18827 and U01-MH79639 to Dr. Kosten and NIMH Grant MH 78775 to Dr. Harvey.
PY - 2011/8
Y1 - 2011/8
N2 - Performance-based assessments of everyday living skills have been shown to be highly correlated with cognitive functioning in schizophrenia and bipolar disorder, as well as being predictive of deficits in real-world outcomes such as independent living and employment. In this study, we expand our assessments of impairments in everyday living skills to China, evaluating people with schizophrenia, bipolar disorder, and major depression, and comparing their performance to that of healthy controls. Samples of people with schizophrenia (n = 272), bipolar disorder (n = 61), major depression (n = 50), and healthy controls (n = 284) were examined with the Chinese version of the UCSD performance-based assessment, brief version (UPSA-B). Performance was compared across the groups and the association between age, gender, educational attainment, marital status, and UPSA-B scores was evaluated. When the performance on the UPSA was compared across the groups, with education as a covariate, significant effects of both diagnosis (F = 86.3, p <.001) and education were found (F = 228.3, p <.001). Sex and age did not contribute significantly when age and education were considered. Post-hoc comparisons revealed that total UPSA-B scores were lowest in the schizophrenia patients, followed by the patients with major depression. Patients with bipolar disorder did not differ from the healthy comparison subjects on overall performance. Scores for all groups were lower than previously reported in western samples (e.g., HC mean = 64). While diagnostic differences in UPSA-B scores are similar to those previously seen in western samples, the education effect is considerably more substantial. These data suggest that in developing countries educational attainment may be strongly associated with levels of adaptive outcomes and the utilization and interpretation of functional capacity measures be adjusted accordingly.
AB - Performance-based assessments of everyday living skills have been shown to be highly correlated with cognitive functioning in schizophrenia and bipolar disorder, as well as being predictive of deficits in real-world outcomes such as independent living and employment. In this study, we expand our assessments of impairments in everyday living skills to China, evaluating people with schizophrenia, bipolar disorder, and major depression, and comparing their performance to that of healthy controls. Samples of people with schizophrenia (n = 272), bipolar disorder (n = 61), major depression (n = 50), and healthy controls (n = 284) were examined with the Chinese version of the UCSD performance-based assessment, brief version (UPSA-B). Performance was compared across the groups and the association between age, gender, educational attainment, marital status, and UPSA-B scores was evaluated. When the performance on the UPSA was compared across the groups, with education as a covariate, significant effects of both diagnosis (F = 86.3, p <.001) and education were found (F = 228.3, p <.001). Sex and age did not contribute significantly when age and education were considered. Post-hoc comparisons revealed that total UPSA-B scores were lowest in the schizophrenia patients, followed by the patients with major depression. Patients with bipolar disorder did not differ from the healthy comparison subjects on overall performance. Scores for all groups were lower than previously reported in western samples (e.g., HC mean = 64). While diagnostic differences in UPSA-B scores are similar to those previously seen in western samples, the education effect is considerably more substantial. These data suggest that in developing countries educational attainment may be strongly associated with levels of adaptive outcomes and the utilization and interpretation of functional capacity measures be adjusted accordingly.
KW - Bipolar disorder
KW - Depression
KW - Functional capacity
KW - Performance-based assessment
KW - Schizophrenia
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U2 - 10.1016/j.jpsychires.2011.01.012
DO - 10.1016/j.jpsychires.2011.01.012
M3 - Article
C2 - 21300378
AN - SCOPUS:79960600322
VL - 45
SP - 1089
EP - 1094
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
IS - 8
ER -