Abstract
PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-126 |
| Number of pages | 8 |
| Journal | Radiology |
| Volume | 217 |
| Issue number | 1 |
| State | Published - 2000 |
| Externally published | Yes |
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Keywords
- Liver interventional procedures
- Liver neoplasms
- Liver neoplasms, angiography
- Liver neoplasms, CT
- Liver neoplasms, MR
- Radiofrequency (RF) ablation
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 . / Rossi, S.; Garbagnati, F.; Lencioni, Riccardo; Allgaier, H. P.; Marchianó, A.; Fornari, F.; Quaretti, P.; Di Tolla, G.; Ambrosi, C.; Mazzaferro, V.; Blum, H. E.; Bartolozzi, C.
In: Radiology, Vol. 217, No. 1, 2000, p. 119-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1
AU - Rossi, S.
AU - Garbagnati, F.
AU - Lencioni, Riccardo
AU - Allgaier, H. P.
AU - Marchianó, A.
AU - Fornari, F.
AU - Quaretti, P.
AU - Di Tolla, G.
AU - Ambrosi, C.
AU - Mazzaferro, V.
AU - Blum, H. E.
AU - Bartolozzi, C.
PY - 2000
Y1 - 2000
N2 - PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.
AB - PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.
KW - Liver interventional procedures
KW - Liver neoplasms
KW - Liver neoplasms, angiography
KW - Liver neoplasms, CT
KW - Liver neoplasms, MR
KW - Radiofrequency (RF) ablation
UR - http://www.scopus.com/inward/record.url?scp=0034541431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034541431&partnerID=8YFLogxK
M3 - Article
C2 - 11012432
AN - SCOPUS:0034541431
VL - 217
SP - 119
EP - 126
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 1
ER -