Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1

S. Rossi, F. Garbagnati, Riccardo Lencioni, H. P. Allgaier, A. Marchianó, F. Fornari, P. Quaretti, G. Di Tolla, C. Ambrosi, V. Mazzaferro, H. E. Blum, C. Bartolozzi

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalRadiology
Volume217
Issue number1
StatePublished - 2000
Externally publishedYes

Fingerprint

Radio
Hepatocellular Carcinoma
Hot Temperature
Neoplasms
Necrosis
Spiral Computed Tomography
Recurrence
Hepatic Artery
Porifera
Gelatin
Autopsy
Fibrosis
Catheters
Arteries
Biopsy
Survival

Keywords

  • Liver interventional procedures
  • Liver neoplasms
  • Liver neoplasms, angiography
  • Liver neoplasms, CT
  • Liver neoplasms, MR
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Rossi, S., Garbagnati, F., Lencioni, R., Allgaier, H. P., Marchianó, A., Fornari, F., ... Bartolozzi, C. (2000). Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 . Radiology, 217(1), 119-126.

Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 . / Rossi, S.; Garbagnati, F.; Lencioni, Riccardo; Allgaier, H. P.; Marchianó, A.; Fornari, F.; Quaretti, P.; Di Tolla, G.; Ambrosi, C.; Mazzaferro, V.; Blum, H. E.; Bartolozzi, C.

In: Radiology, Vol. 217, No. 1, 2000, p. 119-126.

Research output: Contribution to journalArticle

Rossi, S, Garbagnati, F, Lencioni, R, Allgaier, HP, Marchianó, A, Fornari, F, Quaretti, P, Di Tolla, G, Ambrosi, C, Mazzaferro, V, Blum, HE & Bartolozzi, C 2000, 'Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 ', Radiology, vol. 217, no. 1, pp. 119-126.
Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchianó A, Fornari F et al. Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 . Radiology. 2000;217(1):119-126.
Rossi, S. ; Garbagnati, F. ; Lencioni, Riccardo ; Allgaier, H. P. ; Marchianó, A. ; Fornari, F. ; Quaretti, P. ; Di Tolla, G. ; Ambrosi, C. ; Mazzaferro, V. ; Blum, H. E. ; Bartolozzi, C. / Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply1 . In: Radiology. 2000 ; Vol. 217, No. 1. pp. 119-126.
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abstract = "PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40{\%}-75{\%} reduction in maximum diameter. The 1-year estimate of failure risk was 19{\%} for local recurrence and 45{\%} for overall intrahepatic recurrence. The estimated 1-year survival was 87{\%}. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90{\%} necrosis in one specimen and 100{\%} necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.",
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AU - Rossi, S.

AU - Garbagnati, F.

AU - Lencioni, Riccardo

AU - Allgaier, H. P.

AU - Marchianó, A.

AU - Fornari, F.

AU - Quaretti, P.

AU - Di Tolla, G.

AU - Ambrosi, C.

AU - Mazzaferro, V.

AU - Blum, H. E.

AU - Bartolozzi, C.

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N2 - PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.

AB - PURPOSE: To evaluate the usefulness of percutaneous radio-frequency (RF) thermal ablation of nonresectable hepatocellular carcinoma (HCC) after occlusion of the tumor arterial supply. MATERIALS AND METHODS: Sixty-two patients with cirrhosis and biopsy-proved HCC underwent RF ablation after interruption of the tumor arterial supply by means of occlusion of either the hepatic artery with a balloon catheter (40 patients) or the feeding arteries with gelatin sponge particles (22 patients). RESULTS: After a single RF procedure in 56 patients and after two procedures in six patients, spiral computed tomography (CT) demonstrated a nonenhancing area corresponding in shape to the previously identified HCC, which was suggestive of complete necrosis. No major complications occurred. Two patients subsequently underwent surgical resection; the remaining 60 patients were followed up with spiral CT. During a mean follow-up of 12.1 months, 11 HCC nodules showed areas of local progression; 49 were identified as nonenhancing areas with a 40%-75% reduction in maximum diameter. The 1-year estimate of failure risk was 19% for local recurrence and 45% for overall intrahepatic recurrence. The estimated 1-year survival was 87%. Histopathologic analysis of one autopsy and two surgical specimens revealed more than 90% necrosis in one specimen and 100% necrosis in two. CONCLUSION: HCC nodules 3.5-8.5 cm in diameter can be ablated in one or two RF sessions after occlusion of the tumor arterial supply.

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