Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease

Riccardo Lencioni, D. Caramella, C. Bartolozzi, S. Mazzeo, G. Di Coscio

Research output: Contribution to journalArticle

Abstract

Adenomatous hyperplastic nodules (AHNs) in cirrhotic liver are considered a precancerous condition which may lead to hepatocellular carcinoma (HCC). In this study, we treated a total of 23 AHNs in 15 patients with percutaneous ethanol injection (PEI). The treatment included 6 to 8 PEIs, performed on an out-patient basis under sonographic guidance. A 22 G (0.7 mm) spinal needle was used. The total amount of alcohol delivered into each lesion was 8 to 25 ml (mean 14.9 ml). At the end of treatment, complete necrosis of the nodule was proved in all cases by multiple fine-needle biopsies and confirmed by CT and MR findings. During follow-up (9–41 months, mean 24 months) no recurrences were demonstrated. However, HCC occurred elsewhere in the liver of 4 patients and additional AHNs were detected in 2 patients. Thus, PEI proved able to cause complete ablation of AHNs, presumably preventing their malignant transformation. However, patients with AHN remain at high risk for developing HCC.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalActa Radiologica
Volume35
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Liver Diseases
Ethanol
Hepatocellular Carcinoma
Injections
Precancerous Conditions
Liver
Therapeutics
Fine Needle Biopsy
Needles
Necrosis
Outpatients
Alcohols
Recurrence

Keywords

  • CT
  • interventional procedure
  • Liver, cirrhosis
  • MR
  • neoplasms
  • therapy
  • US studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease. / Lencioni, Riccardo; Caramella, D.; Bartolozzi, C.; Mazzeo, S.; Coscio, G. Di.

In: Acta Radiologica, Vol. 35, No. 2, 1994, p. 138-142.

Research output: Contribution to journalArticle

Lencioni, R, Caramella, D, Bartolozzi, C, Mazzeo, S & Coscio, GD 1994, 'Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease', Acta Radiologica, vol. 35, no. 2, pp. 138-142. https://doi.org/10.1177/028418519403500207
Lencioni, Riccardo ; Caramella, D. ; Bartolozzi, C. ; Mazzeo, S. ; Coscio, G. Di. / Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease. In: Acta Radiologica. 1994 ; Vol. 35, No. 2. pp. 138-142.
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