Percutaneous ethanol injection therapy of adenomatous hyperplastic nodules in cirrhotic liver disease

R. Lencioni, D. Caramella, C. Bartolozzi, S. Mazzeo, G. Di Coscio

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18 Scopus citations


Adenomatous hyperplastic nodules (AHNs) in cirrhotic liver are considered a precancerous condition which may lead to hepatocellular carcinoma (HCC). In this study, we treated a total of 23 AHNs in 15 patients with percutaneous ethanol injection (PEI). The treatment included 6 to 8 PEIs, performed on an out-patient basis under sonographic guidance. A 22 G (0.7 mm) spinal needle was used. The total amount of alcohol delivered into each lesion was 8 to 25 ml (mean 14.9 ml). At the end of treatment, complete necrosis of the nodule was proved in all cases by multiple fine-needle biopsies and confirmed by CT and MR findings. During follow-up (9–41 months, mean 24 months) no recurrences were demonstrated. However, HCC occurred elsewhere in the liver of 4 patients and additional AHNs were detected in 2 patients. Thus, PEI proved able to cause complete ablation of AHNs, presumably preventing their malignant transformation. However, patients with AHN remain at high risk for developing HCC.

Original languageEnglish (US)
Pages (from-to)138-142
Number of pages5
JournalActa Radiologica
Issue number2
StatePublished - Mar 1994


  • CT
  • Liver, cirrhosis
  • MR
  • US studies
  • interventional procedure
  • neoplasms
  • therapy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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