Percutaneous absorption of crotamiton in man following single and multiple dosing

Emi Dika, A. Tosti, M. Goldovsky, R. Wester, H. I. Maibach

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. Methods: We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose regimen by measuring urinary excretion and liquid scintillation counting in three groups of four healthy volunteers. The Feldmann urinary excretion method was utilized to ascertain percutaneous absorption. Our results showed that tape stripping does not increase percutaneous absorption of crotamiton; upon repeated application.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalCutaneous and Ocular Toxicology
Volume25
Issue number3
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Keywords

  • Crotamiton
  • Percutaneous absorption

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Ophthalmology
  • Toxicology

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