Peptide YY-like immunoreactivity in sympathetic neurons of the rat

O. Häppölä, Claes R Wahlestedt, R. Ekman, S. Soinila, P. Panula, R. Håkanson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The occurrence of peptide YY-like peptides in parts of the sympathetic nervous system of the rat was studied by immunocytochemistry and immunochemistry plus analysis by high performance liquid chromatography. Peptide YY-immunoreactive neurons and nerve fibers were detected in the superior cervical ganglion. Co-localization studies indicated that peptide YY and neuropeptide Y immunoreactivities co-exist in a subpopulation of neurons of the superior cervical ganglion. Immunochemical analysis revealed peptide YY-immunoreactive material, distinct from neuropeptide Y, in extracts of the superior cervical ganglion. On reverse-phase high performance liquid chromatography, extracts of superior cervical ganglion revealed several peaks of peptide YY-like immunoreactive material, one of which eluted close to the position of authentic porcine peptide YY. Peptide YY-immunoreactive nerve fibers were also present in sympathetic target tissues including the auricula and atria of the heart, carotid body, submandibular salivary gland and the adrenal cortex. It is suggested that peptide YY and/or peptide YY-like peptides are present not only in endocrine cells, but also in a subpopulation of cell bodies and fibers of the peripheral sympathetic nervous system.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalNeuroscience
Volume39
Issue number1
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Peptide YY
Neurons
Superior Cervical Ganglion
Neuropeptide Y
Sympathetic Nervous System
Nerve Fibers
High Pressure Liquid Chromatography
Immunochemistry
Carotid Body
Peptides
Endocrine Cells
Submandibular Gland
Adrenal Cortex
Peripheral Nervous System
Reverse-Phase Chromatography
Salivary Glands
Heart Atria
Swine
Immunohistochemistry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Häppölä, O., Wahlestedt, C. R., Ekman, R., Soinila, S., Panula, P., & Håkanson, R. (1990). Peptide YY-like immunoreactivity in sympathetic neurons of the rat. Neuroscience, 39(1), 225-230. https://doi.org/10.1016/0306-4522(90)90235-V

Peptide YY-like immunoreactivity in sympathetic neurons of the rat. / Häppölä, O.; Wahlestedt, Claes R; Ekman, R.; Soinila, S.; Panula, P.; Håkanson, R.

In: Neuroscience, Vol. 39, No. 1, 01.01.1990, p. 225-230.

Research output: Contribution to journalArticle

Häppölä, O, Wahlestedt, CR, Ekman, R, Soinila, S, Panula, P & Håkanson, R 1990, 'Peptide YY-like immunoreactivity in sympathetic neurons of the rat', Neuroscience, vol. 39, no. 1, pp. 225-230. https://doi.org/10.1016/0306-4522(90)90235-V
Häppölä, O. ; Wahlestedt, Claes R ; Ekman, R. ; Soinila, S. ; Panula, P. ; Håkanson, R. / Peptide YY-like immunoreactivity in sympathetic neurons of the rat. In: Neuroscience. 1990 ; Vol. 39, No. 1. pp. 225-230.
@article{c9ca87a91d384b008c22fc060f72d378,
title = "Peptide YY-like immunoreactivity in sympathetic neurons of the rat",
abstract = "The occurrence of peptide YY-like peptides in parts of the sympathetic nervous system of the rat was studied by immunocytochemistry and immunochemistry plus analysis by high performance liquid chromatography. Peptide YY-immunoreactive neurons and nerve fibers were detected in the superior cervical ganglion. Co-localization studies indicated that peptide YY and neuropeptide Y immunoreactivities co-exist in a subpopulation of neurons of the superior cervical ganglion. Immunochemical analysis revealed peptide YY-immunoreactive material, distinct from neuropeptide Y, in extracts of the superior cervical ganglion. On reverse-phase high performance liquid chromatography, extracts of superior cervical ganglion revealed several peaks of peptide YY-like immunoreactive material, one of which eluted close to the position of authentic porcine peptide YY. Peptide YY-immunoreactive nerve fibers were also present in sympathetic target tissues including the auricula and atria of the heart, carotid body, submandibular salivary gland and the adrenal cortex. It is suggested that peptide YY and/or peptide YY-like peptides are present not only in endocrine cells, but also in a subpopulation of cell bodies and fibers of the peripheral sympathetic nervous system.",
author = "O. H{\"a}pp{\"o}l{\"a} and Wahlestedt, {Claes R} and R. Ekman and S. Soinila and P. Panula and R. H{\aa}kanson",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0306-4522(90)90235-V",
language = "English",
volume = "39",
pages = "225--230",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Peptide YY-like immunoreactivity in sympathetic neurons of the rat

AU - Häppölä, O.

AU - Wahlestedt, Claes R

AU - Ekman, R.

AU - Soinila, S.

AU - Panula, P.

AU - Håkanson, R.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The occurrence of peptide YY-like peptides in parts of the sympathetic nervous system of the rat was studied by immunocytochemistry and immunochemistry plus analysis by high performance liquid chromatography. Peptide YY-immunoreactive neurons and nerve fibers were detected in the superior cervical ganglion. Co-localization studies indicated that peptide YY and neuropeptide Y immunoreactivities co-exist in a subpopulation of neurons of the superior cervical ganglion. Immunochemical analysis revealed peptide YY-immunoreactive material, distinct from neuropeptide Y, in extracts of the superior cervical ganglion. On reverse-phase high performance liquid chromatography, extracts of superior cervical ganglion revealed several peaks of peptide YY-like immunoreactive material, one of which eluted close to the position of authentic porcine peptide YY. Peptide YY-immunoreactive nerve fibers were also present in sympathetic target tissues including the auricula and atria of the heart, carotid body, submandibular salivary gland and the adrenal cortex. It is suggested that peptide YY and/or peptide YY-like peptides are present not only in endocrine cells, but also in a subpopulation of cell bodies and fibers of the peripheral sympathetic nervous system.

AB - The occurrence of peptide YY-like peptides in parts of the sympathetic nervous system of the rat was studied by immunocytochemistry and immunochemistry plus analysis by high performance liquid chromatography. Peptide YY-immunoreactive neurons and nerve fibers were detected in the superior cervical ganglion. Co-localization studies indicated that peptide YY and neuropeptide Y immunoreactivities co-exist in a subpopulation of neurons of the superior cervical ganglion. Immunochemical analysis revealed peptide YY-immunoreactive material, distinct from neuropeptide Y, in extracts of the superior cervical ganglion. On reverse-phase high performance liquid chromatography, extracts of superior cervical ganglion revealed several peaks of peptide YY-like immunoreactive material, one of which eluted close to the position of authentic porcine peptide YY. Peptide YY-immunoreactive nerve fibers were also present in sympathetic target tissues including the auricula and atria of the heart, carotid body, submandibular salivary gland and the adrenal cortex. It is suggested that peptide YY and/or peptide YY-like peptides are present not only in endocrine cells, but also in a subpopulation of cell bodies and fibers of the peripheral sympathetic nervous system.

UR - http://www.scopus.com/inward/record.url?scp=0025243381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025243381&partnerID=8YFLogxK

U2 - 10.1016/0306-4522(90)90235-V

DO - 10.1016/0306-4522(90)90235-V

M3 - Article

VL - 39

SP - 225

EP - 230

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 1

ER -