TY - JOUR
T1 - Peptide-Modified Biopolymers for Biomedical Applications
AU - Hersh, Jessica
AU - Broyles, David
AU - Capcha, José Manuel Condor
AU - Dikici, Emre
AU - Shehadeh, Lina A.
AU - Daunert, Sylvia
AU - Deo, Sapna
N1 - Funding Information:
The authors would like to thank NIGMS (R01GM114321, R01GM127706), NHLBI (R01 HL149452), and the National Science Foundation (CBET-1841419) for funding support. S.D. thanks the Miller School of Medicine of the University of Miami for the Lucille P. Markey Chair in Biochemistry and Molecular Biology. J.H. thanks the University of Miami Dean’s Fellowship for funding.
Publisher Copyright:
©
PY - 2021/1/18
Y1 - 2021/1/18
N2 - Polymeric biomaterials have been used in a variety of applications, like cargo delivery and tissue scaffolding, because they are easily synthesized and can be adapted to many systems. However, there is still a need to further enhance and improve their functions to progress their use in the biomedical field. A promising solution is to modify the polymer surfaces with peptides that can increase biocompatibility, cellular interactions, and receptor targeting. In recent years, peptide modifications have been used to overcome many challenges to polymer biomaterial development. This review discusses recent progress in developing peptide-modified polymers for therapeutic applications including cell-specific targeting and tissue engineering. Furthermore, we will explore some of the most frequently studied base components of these biomaterials.
AB - Polymeric biomaterials have been used in a variety of applications, like cargo delivery and tissue scaffolding, because they are easily synthesized and can be adapted to many systems. However, there is still a need to further enhance and improve their functions to progress their use in the biomedical field. A promising solution is to modify the polymer surfaces with peptides that can increase biocompatibility, cellular interactions, and receptor targeting. In recent years, peptide modifications have been used to overcome many challenges to polymer biomaterial development. This review discusses recent progress in developing peptide-modified polymers for therapeutic applications including cell-specific targeting and tissue engineering. Furthermore, we will explore some of the most frequently studied base components of these biomaterials.
KW - peptide modifications
KW - polymeric therapeutics
KW - polymers
KW - targeting
KW - tissue engineering
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U2 - 10.1021/acsabm.0c01145
DO - 10.1021/acsabm.0c01145
M3 - Review article
AN - SCOPUS:85099096722
VL - 4
SP - 229
EP - 251
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
SN - 2576-6422
IS - 1
ER -