Peptide-Modified Biopolymers for Biomedical Applications

Jessica Hersh, David Broyles, José Manuel Condor Capcha, Emre Dikici, Lina A. Shehadeh, Sylvia Daunert, Sapna Deo

Research output: Contribution to journalReview articlepeer-review

Abstract

Polymeric biomaterials have been used in a variety of applications, like cargo delivery and tissue scaffolding, because they are easily synthesized and can be adapted to many systems. However, there is still a need to further enhance and improve their functions to progress their use in the biomedical field. A promising solution is to modify the polymer surfaces with peptides that can increase biocompatibility, cellular interactions, and receptor targeting. In recent years, peptide modifications have been used to overcome many challenges to polymer biomaterial development. This review discusses recent progress in developing peptide-modified polymers for therapeutic applications including cell-specific targeting and tissue engineering. Furthermore, we will explore some of the most frequently studied base components of these biomaterials.

Original languageEnglish (US)
Pages (from-to)229-251
Number of pages23
JournalACS Applied Bio Materials
Volume4
Issue number1
DOIs
StatePublished - Jan 18 2021

Keywords

  • peptide modifications
  • polymeric therapeutics
  • polymers
  • targeting
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

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