Peptide-functionalized polymeric nanoparticles for active targeting of damaged tissue in animals with experimental autoimmune encephalomyelitis

Tobias Führmann, Mousumi Ghosh, Anthony Otero, Ben Goss, Tim R. Dargaville, Damien D Pearse, Paul D. Dalton

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Increased permeability of blood vessels is an indicator for various injuries and diseases, including multiple sclerosis (MS), of the central nervous system. Nanoparticles have the potential to deliver drugs locally to sites of tissue damage, reducing the drug administered and limiting associated side effects, but efficient accumulation still remains a challenge. We developed peptide-functionalized polymeric nanoparticles to target blood clots and the extracellular matrix molecule nidogen, which are associated with areas of tissue damage. Using the induction of experimental autoimmune encephalomyelitis in rats to provide a model of MS associated with tissue damage and blood vessel lesions, all targeted nanoparticles were delivered systemically. In vivo data demonstrates enhanced accumulation of peptide functionalized nanoparticles at the injury site compared to scrambled and naive controls, particularly for nanoparticles functionalized to target fibrin clots. This suggests that further investigations with drug laden, peptide functionalized nanoparticles might be of particular interest in the development of treatment strategies for MS.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalNeuroscience Letters
Volume602
DOIs
StatePublished - Aug 8 2015

Keywords

  • Multiple sclerosis
  • Nanoparticles
  • Spinal cord
  • Targeted delivery

ASJC Scopus subject areas

  • Neuroscience(all)

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