Abstract
A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 262 |
| Number of pages | 1 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
Keywords
- Amide bond
- Amino acid residues
- Catalysis
- Hydrolysis
- Metallopeptidase
- Protease
- Synthetic analogues
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
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Cite this
Prabhakar, R. (2013). Peptide Bond. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 262). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.01133-5