Peptide Bond

Rajeev Prabhakar

doi:10.1016/B978-0-12-374984-0.01133-5

Peptide Bond

Rajeev Prabhakar

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.

Original language	English (US)
Title of host publication	Brenner's Encyclopedia of Genetics
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	262
Number of pages	1
ISBN (Electronic)	9780080961569
ISBN (Print)	9780123749840
DOIs	https://doi.org/10.1016/B978-0-12-374984-0.01133-5
State	Published - Feb 27 2013

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Keywords

Amide bond
Amino acid residues
Catalysis
Hydrolysis
Metallopeptidase
Protease
Synthetic analogues

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Cite this

Prabhakar, R. (2013). Peptide Bond. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 262). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.01133-5

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KW - Synthetic analogues

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Access to Document

10.1016/B978-0-12-374984-0.01133-5