Abstract
A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 262 |
| Number of pages | 1 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
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Keywords
- Amide bond
- Amino acid residues
- Catalysis
- Hydrolysis
- Metallopeptidase
- Protease
- Synthetic analogues
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Peptide Bond. / Prabhakar, Rajeev.
Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., 2013. p. 262.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Peptide Bond
AU - Prabhakar, Rajeev
PY - 2013/2/27
Y1 - 2013/2/27
N2 - A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.
AB - A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.
KW - Amide bond
KW - Amino acid residues
KW - Catalysis
KW - Hydrolysis
KW - Metallopeptidase
KW - Protease
KW - Synthetic analogues
UR - http://www.scopus.com/inward/record.url?scp=85043228562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043228562&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-374984-0.01133-5
DO - 10.1016/B978-0-12-374984-0.01133-5
M3 - Chapter
SN - 9780123749840
SP - 262
BT - Brenner's Encyclopedia of Genetics
PB - Elsevier Inc.
ER -