Peptide Bond

Research output: Chapter in Book/Report/Conference proceedingChapter


A peptide or amide (-CO-NH-) bond is formed by the linking of the carboxyl group of one amino acid with the amino group of another with the loss of a water molecule. In this bond, the oxygen atom of the carbonyl group is in the trans position with respect to the hydrogen on the nitrogen atom and all of these four atoms are planar due to resonance. This bond has a partially (40%) double-bond character, and the half-life for the hydrolysis of peptide bonds is 350-600 years at room temperature and at pH 4-8. The selective hydrolysis of the peptide bond of peptides and proteins is required in a wide range of biological, biotechnological, and industrial applications.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages1
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013


  • Amide bond
  • Amino acid residues
  • Catalysis
  • Hydrolysis
  • Metallopeptidase
  • Protease
  • Synthetic analogues

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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