Peptide and non-peptide bradykinin receptor antagonists: Role in allergic airway disease

William M. Abraham, Mario Scuri, Stephen G. Farmer

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Kinins are proinflammatory peptides that mediate a variety of pathophysiological responses. These actions occur through stimulation of two pharmacologically distinct receptor subtypes B1 and B2. In both human and animal airways, the majority of kinin-induced effects including bronchoconstriction, increases in vascular permeability and mucus secretion and cholinergic and sensory nerve stimulation appear to be bradykinin B 2-receptor mediated. Peptidic and non-peptidic receptor antagonists have been developed as potential therapeutic agents. These antagonists are effective in blocking kinin-induced effects in a variety of animal models and in some instances, have been used effectively in animal models of allergic airway disease to alleviate allergen-induced pathophysiological airway responses. This review summarizes relevant studies supporting the evidence that bradykinin B2 receptor antagonism and/or upstream inhibition of tissue kallikrein will be beneficial in the treatment of inflammatory airway diseases.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalEuropean Journal of Pharmacology
Volume533
Issue number1-3
DOIs
StatePublished - Mar 8 2006

Keywords

  • Airway inflammation
  • Animal model
  • Asthma
  • Kinin
  • Therapy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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