Pentylenetetrazol: Facilitation of classical discrimination conditioning in rabbits

Richard Elliott; Neil Schneiderman

doi:10.1007/BF00401543

Pentylenetetrazol: Facilitation of classical discrimination conditioning in rabbits

Richard Elliott, Neil Schneiderman

Psychology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Subcutaneous injections of pentylenetetrazol (25 mg/kg) reliably increased the rate of nictitating membrane acquisition and enhanced a respiration rate discrimination between stimuli, while leaving rate of heart rate conditioning and discrimination formation unaffected. These effects were response and dosage dependent, with the greatest enhancement of performance occurring at dosages just under the convulsion threshold. The data suggest that pentylenetetrazol enhanced performance in the nictitating membrane response system by increasing the probability that Ss would move from an inactive to an active response state.

Original language	English (US)
Pages (from-to)	133-141
Number of pages	9
Journal	Psychopharmacologia
Volume	12
Issue number	2
DOIs	https://doi.org/10.1007/BF00401543
State	Published - Jan 1 1968

ASJC Scopus subject areas

Pharmacology

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abstract = "Subcutaneous injections of pentylenetetrazol (25 mg/kg) reliably increased the rate of nictitating membrane acquisition and enhanced a respiration rate discrimination between stimuli, while leaving rate of heart rate conditioning and discrimination formation unaffected. These effects were response and dosage dependent, with the greatest enhancement of performance occurring at dosages just under the convulsion threshold. The data suggest that pentylenetetrazol enhanced performance in the nictitating membrane response system by increasing the probability that Ss would move from an inactive to an active response state.",

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