Pentylenetetrazol: Facilitation of classical discrimination conditioning in rabbits

Richard Elliott, Neil Schneiderman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Subcutaneous injections of pentylenetetrazol (25 mg/kg) reliably increased the rate of nictitating membrane acquisition and enhanced a respiration rate discrimination between stimuli, while leaving rate of heart rate conditioning and discrimination formation unaffected. These effects were response and dosage dependent, with the greatest enhancement of performance occurring at dosages just under the convulsion threshold. The data suggest that pentylenetetrazol enhanced performance in the nictitating membrane response system by increasing the probability that Ss would move from an inactive to an active response state.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalPsychopharmacologia
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1968

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ASJC Scopus subject areas

  • Pharmacology

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