Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits

David L. Walton, Donald Willis, Octavio V. Martinez, Rita Fojaco, Victor P. Chin, Mary Jo O'Sullivan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Our purpose was to determine whether pentoxifylline, a potent cytokine inhibitor, would delay bacterially induced preterm delivery in rabbits. Study design: The study was a randomized, blinded, prospective trial. Twenty-seven rabbits underwent laparotomy. Of these, five (shams) received an intrauterine injection of endotoxin-free water, and the remaining 22 received an injection of 105 Escherichia coli into the lower uterine segment. Postoperatively the animals that received the Escherichia coli were divided into two groups. The placebo group (n = 11) received subcutaneous injections of saline solution three times a day and the treatment group (n = 11) received pentoxifylline 20 mg/kg/day in three divided doses. The following parameters were evaluated: (1) time until delivery, (2) time until death, and (3) intrauterine pathologic features. Results: All five of the sham rabbits were delivered at term without any evidence of infection. There were no differences in the preterm delivery rates between the placebo group (eight of 11) and the pentoxifylline-treated group (seven to 11). However, there was a trend toward prolonging time until death in the treatment group. There were no differences in intrauterine pathologic feature between the placebo and treatment groups. Conclusion: Pentoxifylline does not delay Escherichia coli induced preterm delivery in rabbits.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalJournal of Perinatology
Volume16
Issue number4
StatePublished - Jul 1 1996

Fingerprint

Pentoxifylline
Rabbits
Placebos
Escherichia coli
Injections
Subcutaneous Injections
Endotoxins
Sodium Chloride
Laparotomy
Therapeutics
Cytokines
Water
Infection

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Walton, D. L., Willis, D., Martinez, O. V., Fojaco, R., Chin, V. P., & O'Sullivan, M. J. (1996). Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits. Journal of Perinatology, 16(4), 281-284.

Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits. / Walton, David L.; Willis, Donald; Martinez, Octavio V.; Fojaco, Rita; Chin, Victor P.; O'Sullivan, Mary Jo.

In: Journal of Perinatology, Vol. 16, No. 4, 01.07.1996, p. 281-284.

Research output: Contribution to journalArticle

Walton, DL, Willis, D, Martinez, OV, Fojaco, R, Chin, VP & O'Sullivan, MJ 1996, 'Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits', Journal of Perinatology, vol. 16, no. 4, pp. 281-284.
Walton DL, Willis D, Martinez OV, Fojaco R, Chin VP, O'Sullivan MJ. Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits. Journal of Perinatology. 1996 Jul 1;16(4):281-284.
Walton, David L. ; Willis, Donald ; Martinez, Octavio V. ; Fojaco, Rita ; Chin, Victor P. ; O'Sullivan, Mary Jo. / Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits. In: Journal of Perinatology. 1996 ; Vol. 16, No. 4. pp. 281-284.
@article{e68967382daa41adbbbcac64b7385b06,
title = "Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits",
abstract = "Objective: Our purpose was to determine whether pentoxifylline, a potent cytokine inhibitor, would delay bacterially induced preterm delivery in rabbits. Study design: The study was a randomized, blinded, prospective trial. Twenty-seven rabbits underwent laparotomy. Of these, five (shams) received an intrauterine injection of endotoxin-free water, and the remaining 22 received an injection of 105 Escherichia coli into the lower uterine segment. Postoperatively the animals that received the Escherichia coli were divided into two groups. The placebo group (n = 11) received subcutaneous injections of saline solution three times a day and the treatment group (n = 11) received pentoxifylline 20 mg/kg/day in three divided doses. The following parameters were evaluated: (1) time until delivery, (2) time until death, and (3) intrauterine pathologic features. Results: All five of the sham rabbits were delivered at term without any evidence of infection. There were no differences in the preterm delivery rates between the placebo group (eight of 11) and the pentoxifylline-treated group (seven to 11). However, there was a trend toward prolonging time until death in the treatment group. There were no differences in intrauterine pathologic feature between the placebo and treatment groups. Conclusion: Pentoxifylline does not delay Escherichia coli induced preterm delivery in rabbits.",
author = "Walton, {David L.} and Donald Willis and Martinez, {Octavio V.} and Rita Fojaco and Chin, {Victor P.} and O'Sullivan, {Mary Jo}",
year = "1996",
month = "7",
day = "1",
language = "English",
volume = "16",
pages = "281--284",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Pentoxifylline Does Not Delay Bacterially Induced Preterm Delivery in Rabbits

AU - Walton, David L.

AU - Willis, Donald

AU - Martinez, Octavio V.

AU - Fojaco, Rita

AU - Chin, Victor P.

AU - O'Sullivan, Mary Jo

PY - 1996/7/1

Y1 - 1996/7/1

N2 - Objective: Our purpose was to determine whether pentoxifylline, a potent cytokine inhibitor, would delay bacterially induced preterm delivery in rabbits. Study design: The study was a randomized, blinded, prospective trial. Twenty-seven rabbits underwent laparotomy. Of these, five (shams) received an intrauterine injection of endotoxin-free water, and the remaining 22 received an injection of 105 Escherichia coli into the lower uterine segment. Postoperatively the animals that received the Escherichia coli were divided into two groups. The placebo group (n = 11) received subcutaneous injections of saline solution three times a day and the treatment group (n = 11) received pentoxifylline 20 mg/kg/day in three divided doses. The following parameters were evaluated: (1) time until delivery, (2) time until death, and (3) intrauterine pathologic features. Results: All five of the sham rabbits were delivered at term without any evidence of infection. There were no differences in the preterm delivery rates between the placebo group (eight of 11) and the pentoxifylline-treated group (seven to 11). However, there was a trend toward prolonging time until death in the treatment group. There were no differences in intrauterine pathologic feature between the placebo and treatment groups. Conclusion: Pentoxifylline does not delay Escherichia coli induced preterm delivery in rabbits.

AB - Objective: Our purpose was to determine whether pentoxifylline, a potent cytokine inhibitor, would delay bacterially induced preterm delivery in rabbits. Study design: The study was a randomized, blinded, prospective trial. Twenty-seven rabbits underwent laparotomy. Of these, five (shams) received an intrauterine injection of endotoxin-free water, and the remaining 22 received an injection of 105 Escherichia coli into the lower uterine segment. Postoperatively the animals that received the Escherichia coli were divided into two groups. The placebo group (n = 11) received subcutaneous injections of saline solution three times a day and the treatment group (n = 11) received pentoxifylline 20 mg/kg/day in three divided doses. The following parameters were evaluated: (1) time until delivery, (2) time until death, and (3) intrauterine pathologic features. Results: All five of the sham rabbits were delivered at term without any evidence of infection. There were no differences in the preterm delivery rates between the placebo group (eight of 11) and the pentoxifylline-treated group (seven to 11). However, there was a trend toward prolonging time until death in the treatment group. There were no differences in intrauterine pathologic feature between the placebo and treatment groups. Conclusion: Pentoxifylline does not delay Escherichia coli induced preterm delivery in rabbits.

UR - http://www.scopus.com/inward/record.url?scp=0030178910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030178910&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 281

EP - 284

JO - Journal of Perinatology

JF - Journal of Perinatology

SN - 0743-8346

IS - 4

ER -