PEG-based hydrogel synthesis via the photodimerization of anthracene groups

Yujun Zheng, Miodrag Micic, Sarita V. Mello, Mustapha Mabrouki, Fotios M Andreopoulos, Veeranjaneyulu Konka, Si M. Pham, Roger Leblanc

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracene-carboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4%. The PEG-anthracene macromers (PEG-AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG-AN hydrogel, including swellability, absorption spectrum, and topography.

Original languageEnglish
Pages (from-to)5228-5234
Number of pages7
JournalMacromolecules
Volume35
Issue number13
DOIs
StatePublished - Jun 18 2002

Fingerprint

Anthracene
Hydrogel
Hydrogels
Polyethylene glycols
Wavelength
Irradiation
Photosensitivity
Intelligent materials
Carboxylic acids
Hydroxyl Radical
Light absorption
Topography
Absorption spectra
Polymers
Substitution reactions
Molecular weight
anthracene
Catalysts

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

PEG-based hydrogel synthesis via the photodimerization of anthracene groups. / Zheng, Yujun; Micic, Miodrag; Mello, Sarita V.; Mabrouki, Mustapha; Andreopoulos, Fotios M; Konka, Veeranjaneyulu; Pham, Si M.; Leblanc, Roger.

In: Macromolecules, Vol. 35, No. 13, 18.06.2002, p. 5228-5234.

Research output: Contribution to journalArticle

Zheng, Y, Micic, M, Mello, SV, Mabrouki, M, Andreopoulos, FM, Konka, V, Pham, SM & Leblanc, R 2002, 'PEG-based hydrogel synthesis via the photodimerization of anthracene groups', Macromolecules, vol. 35, no. 13, pp. 5228-5234. https://doi.org/10.1021/ma012263z
Zheng, Yujun ; Micic, Miodrag ; Mello, Sarita V. ; Mabrouki, Mustapha ; Andreopoulos, Fotios M ; Konka, Veeranjaneyulu ; Pham, Si M. ; Leblanc, Roger. / PEG-based hydrogel synthesis via the photodimerization of anthracene groups. In: Macromolecules. 2002 ; Vol. 35, No. 13. pp. 5228-5234.
@article{d6156f9814a5428d942d1b46ff82451d,
title = "PEG-based hydrogel synthesis via the photodimerization of anthracene groups",
abstract = "Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracene-carboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4{\%}. The PEG-anthracene macromers (PEG-AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG-AN hydrogel, including swellability, absorption spectrum, and topography.",
author = "Yujun Zheng and Miodrag Micic and Mello, {Sarita V.} and Mustapha Mabrouki and Andreopoulos, {Fotios M} and Veeranjaneyulu Konka and Pham, {Si M.} and Roger Leblanc",
year = "2002",
month = "6",
day = "18",
doi = "10.1021/ma012263z",
language = "English",
volume = "35",
pages = "5228--5234",
journal = "Macromolecules",
issn = "0024-9297",
publisher = "American Chemical Society",
number = "13",

}

TY - JOUR

T1 - PEG-based hydrogel synthesis via the photodimerization of anthracene groups

AU - Zheng, Yujun

AU - Micic, Miodrag

AU - Mello, Sarita V.

AU - Mabrouki, Mustapha

AU - Andreopoulos, Fotios M

AU - Konka, Veeranjaneyulu

AU - Pham, Si M.

AU - Leblanc, Roger

PY - 2002/6/18

Y1 - 2002/6/18

N2 - Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracene-carboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4%. The PEG-anthracene macromers (PEG-AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG-AN hydrogel, including swellability, absorption spectrum, and topography.

AB - Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracene-carboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4%. The PEG-anthracene macromers (PEG-AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG-AN hydrogel, including swellability, absorption spectrum, and topography.

UR - http://www.scopus.com/inward/record.url?scp=0037130024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037130024&partnerID=8YFLogxK

U2 - 10.1021/ma012263z

DO - 10.1021/ma012263z

M3 - Article

AN - SCOPUS:0037130024

VL - 35

SP - 5228

EP - 5234

JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 13

ER -