PEG-based hydrogel synthesis via the photodimerization of anthracene groups

Yujun Zheng, Miodrag Micic, Sarita V. Mello, Mustapha Mabrouki, Fotios M. Andreopoulos, Veeranjaneyulu Konka, Si M. Pham, Roger M. Leblanc

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracene-carboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4%. The PEG-anthracene macromers (PEG-AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG-AN hydrogel, including swellability, absorption spectrum, and topography.

Original languageEnglish (US)
Pages (from-to)5228-5234
Number of pages7
JournalMacromolecules
Volume35
Issue number13
DOIs
StatePublished - Jun 18 2002

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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