Abstract
In this article, we discuss strategies for selection of families and family members for genetic studies. We will evaluate strategies to sample large families with multiply affected members, sibships, and nuclear families. In addition, we have added a section to discuss sub-sampling within pedigrees for large sequencing studies, particularly when genome-wide SNP chips are available on all members of a pedigree. The type of family sampled for a study will determine the statistical analyses and power of discovery of genetic findings. We will evaluate study designs that maximize power and allow for linkage and association analyses to identify genetic loci predisposing to phenotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e56 |
| Journal | Current Protocols in Human Genetics |
| Volume | 97 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1 2018 |
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Keywords
- Family-based genetic studies
- genome-wide association
- linkage
- next-generation sequencing
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Pedigree Selection and Information Content. / Vardarajan, Badri N.; Beecham, Gary W; Haines, Jonathan L.
In: Current Protocols in Human Genetics, Vol. 97, No. 1, 01.04.2018, p. e56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pedigree Selection and Information Content
AU - Vardarajan, Badri N.
AU - Beecham, Gary W
AU - Haines, Jonathan L.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - In this article, we discuss strategies for selection of families and family members for genetic studies. We will evaluate strategies to sample large families with multiply affected members, sibships, and nuclear families. In addition, we have added a section to discuss sub-sampling within pedigrees for large sequencing studies, particularly when genome-wide SNP chips are available on all members of a pedigree. The type of family sampled for a study will determine the statistical analyses and power of discovery of genetic findings. We will evaluate study designs that maximize power and allow for linkage and association analyses to identify genetic loci predisposing to phenotype.
AB - In this article, we discuss strategies for selection of families and family members for genetic studies. We will evaluate strategies to sample large families with multiply affected members, sibships, and nuclear families. In addition, we have added a section to discuss sub-sampling within pedigrees for large sequencing studies, particularly when genome-wide SNP chips are available on all members of a pedigree. The type of family sampled for a study will determine the statistical analyses and power of discovery of genetic findings. We will evaluate study designs that maximize power and allow for linkage and association analyses to identify genetic loci predisposing to phenotype.
KW - Family-based genetic studies
KW - genome-wide association
KW - linkage
KW - next-generation sequencing
UR - http://www.scopus.com/inward/record.url?scp=85059798980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059798980&partnerID=8YFLogxK
U2 - 10.1002/cphg.56
DO - 10.1002/cphg.56
M3 - Article
C2 - 30040223
AN - SCOPUS:85059798980
VL - 97
SP - e56
JO - Current Protocols in Human Genetics
JF - Current Protocols in Human Genetics
SN - 1934-8266
IS - 1
ER -