Pedigree Selection and Information Content

Badri N. Vardarajan, Gary W Beecham, Jonathan L. Haines

Research output: Contribution to journalArticle

Abstract

In this article, we discuss strategies for selection of families and family members for genetic studies. We will evaluate strategies to sample large families with multiply affected members, sibships, and nuclear families. In addition, we have added a section to discuss sub-sampling within pedigrees for large sequencing studies, particularly when genome-wide SNP chips are available on all members of a pedigree. The type of family sampled for a study will determine the statistical analyses and power of discovery of genetic findings. We will evaluate study designs that maximize power and allow for linkage and association analyses to identify genetic loci predisposing to phenotype.

Original languageEnglish (US)
Pages (from-to)e56
JournalCurrent Protocols in Human Genetics
Volume97
Issue number1
DOIs
StatePublished - Apr 1 2018

Keywords

  • Family-based genetic studies
  • genome-wide association
  • linkage
  • next-generation sequencing

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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