Abstract
Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas. The patient underwent bilateral gonioscopy-assisted transluminal trabeculotomy (GATT) in both eyes, which achieved adequate intraocular pressure control at short-term follow-up. To the authors' knowledge, this is the first report correlating HR-OCT and histopathologic findings in benign mucosal neuroma associated with MEN 2B, and the first description of secondary open-angle glaucoma associated with MEN 2B treated with GATT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 196-198 |
| Number of pages | 3 |
| Journal | Ocular Oncology and Pathology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1 2018 |
Fingerprint
Keywords
- Anterior segment optical coherence tomography
- Gonioscopy-assisted transluminal trabeculotomy
- Juvenile open-angle glaucoma
- Mucosal neuromas
- Multiple endocrine neoplasia type 2B
ASJC Scopus subject areas
- Nursing(all)
Cite this
Pediatric Multiple Endocrine Neoplasia Type 2B : Clinicopathological Correlation of Perilimbal Mucosal Neuromas and Treatment of Secondary Open-Angle Glaucoma. / Chang, Ta; Okafor, Kingsley C.; Cavuoto, Kara M; Dubovy, Sander; Karp, Carol.
In: Ocular Oncology and Pathology, Vol. 4, No. 3, 01.04.2018, p. 196-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pediatric Multiple Endocrine Neoplasia Type 2B
T2 - Clinicopathological Correlation of Perilimbal Mucosal Neuromas and Treatment of Secondary Open-Angle Glaucoma
AU - Chang, Ta
AU - Okafor, Kingsley C.
AU - Cavuoto, Kara M
AU - Dubovy, Sander
AU - Karp, Carol
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas. The patient underwent bilateral gonioscopy-assisted transluminal trabeculotomy (GATT) in both eyes, which achieved adequate intraocular pressure control at short-term follow-up. To the authors' knowledge, this is the first report correlating HR-OCT and histopathologic findings in benign mucosal neuroma associated with MEN 2B, and the first description of secondary open-angle glaucoma associated with MEN 2B treated with GATT.
AB - Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas. The patient underwent bilateral gonioscopy-assisted transluminal trabeculotomy (GATT) in both eyes, which achieved adequate intraocular pressure control at short-term follow-up. To the authors' knowledge, this is the first report correlating HR-OCT and histopathologic findings in benign mucosal neuroma associated with MEN 2B, and the first description of secondary open-angle glaucoma associated with MEN 2B treated with GATT.
KW - Anterior segment optical coherence tomography
KW - Gonioscopy-assisted transluminal trabeculotomy
KW - Juvenile open-angle glaucoma
KW - Mucosal neuromas
KW - Multiple endocrine neoplasia type 2B
UR - http://www.scopus.com/inward/record.url?scp=85051367098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051367098&partnerID=8YFLogxK
U2 - 10.1159/000484053
DO - 10.1159/000484053
M3 - Article
AN - SCOPUS:85051367098
VL - 4
SP - 196
EP - 198
JO - Ocular Oncology and Pathology
JF - Ocular Oncology and Pathology
SN - 2296-4681
IS - 3
ER -