Pediatric lymphomas in Brazil

Gabriela Gualco, Claudete E. Klumb, Glen N Barber, Lawrence M. Weiss, Carlos E. Bacchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE: This study provides the clinical pathological characteristics of 1301 cases of pediatric/adolescent lymphomas in patients from different geographic regions of Brazil METHODS: A retrospective analyses of diagnosed pediatric lymphoma cases in a 10-year period was performed We believe that it represents the largest series of pediatric lymphomas presented from Brazil RESULTS: Non-Hodgkin lymphomas represented 68% of the cases, including those of precursor (36%) and mature (64%) cell origin Mature cell lymphomas comprised 81% of the B-cell phenotype and 19% of the T-cell phenotype Hodgkin lymphomas represented 32% of all cases, including 87% of the classical type and 13% of nodular lymphocyte predominant type The geographic distribution showed 384% of the cases in the Southeast region, 287% in the Northeast, 161% in the South, 88% in the North, and 8% in the Central-west region The distribution by age groups was 15-18 years old, 33%; 11-14 years old, 26%; 6-10 years old, 24%; and 6 years old or younger, 17% Among mature B-cell lymphomas, most of the cases were Burkitt lymphomas (65%), followed by diffuse large B-cell lymphomas (24%) In the mature T-cell group, anaplastic large cell lymphoma, ALK-positive was the most prevalent (57%), followed by peripheral T-cell lymphoma, then not otherwise specified (25%) In the group of classic Hodgkin lymphomas, the main histological subtype was nodular sclerosis (76%) Nodular lymphocyte predominance occurred more frequently than in other seriesCONCLUSION: Some of the results found in this study may reflect the heterogeneous socioeconomical status and environmental factors of the Brazilian population in different regions.

Original languageEnglish
Pages (from-to)1267-1278
Number of pages12
JournalClinics
Volume65
Issue number12
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Brazil
Lymphoma
Pediatrics
Hodgkin Disease
Lymphocytes
Peripheral T-Cell Lymphoma
Anaplastic Large-Cell Lymphoma
T-Lymphocytes
Phenotype
Burkitt Lymphoma
Lymphoma, Large B-Cell, Diffuse
Sclerosis
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
B-Lymphocytes
Age Groups
Population

Keywords

  • Adolescent
  • Brazil
  • Childhood
  • Epidemiology
  • Geographic region
  • Hodgkin lymphoma
  • Lymphomas
  • Pediatric

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gualco, G., Klumb, C. E., Barber, G. N., Weiss, L. M., & Bacchi, C. E. (2010). Pediatric lymphomas in Brazil. Clinics, 65(12), 1267-1278. https://doi.org/10.1590/S1807-59322010001200008

Pediatric lymphomas in Brazil. / Gualco, Gabriela; Klumb, Claudete E.; Barber, Glen N; Weiss, Lawrence M.; Bacchi, Carlos E.

In: Clinics, Vol. 65, No. 12, 01.12.2010, p. 1267-1278.

Research output: Contribution to journalArticle

Gualco, G, Klumb, CE, Barber, GN, Weiss, LM & Bacchi, CE 2010, 'Pediatric lymphomas in Brazil', Clinics, vol. 65, no. 12, pp. 1267-1278. https://doi.org/10.1590/S1807-59322010001200008
Gualco G, Klumb CE, Barber GN, Weiss LM, Bacchi CE. Pediatric lymphomas in Brazil. Clinics. 2010 Dec 1;65(12):1267-1278. https://doi.org/10.1590/S1807-59322010001200008
Gualco, Gabriela ; Klumb, Claudete E. ; Barber, Glen N ; Weiss, Lawrence M. ; Bacchi, Carlos E. / Pediatric lymphomas in Brazil. In: Clinics. 2010 ; Vol. 65, No. 12. pp. 1267-1278.
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