Pediatric cardiomyopathies: Causes, epidemiology, clinical course, preventive strategies and therapies

Steven E Lipshultz, Thomas R. Cochran, David A. Briston, Stefanie R. Brown, Peter J. Sambatakos, Tracie L Miller, Adriana A. Carrillo, Liat Corcia, Janine E Sanchez, Melissa B. Diamond, Michael Freundlich, Danielle Harake, Tamara Gayle, William G. Harmon, Paolo Rusconi, Satinder K Sandhu, James D. Wilkinson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pediatric cardiomyopathies, which are rare but serious disorders of the muscles of the heart, affect at least one in every 100,000 children in the USA. Approximately 40% of children with symptomatic cardiomyopathy undergo heart transplantation or die from cardiac complications within 2 years. However, a significant number of children suffering from cardiomyopathy are surviving into adulthood, making it an important chronic illness for both pediatric and adult clinicians to understand. The natural history, risk factors, prevalence and incidence of this pediatric condition were not fully understood before the 1990s. Questions regarding optimal diagnostic, prognostic and treatment methods remain. Children require long-term follow-up into adulthood in order to identify the factors associated with best clinical practice including diagnostic approaches, as well as optimal treatment approaches. In this article, we comprehensively review current research on various presentations of this disease, along with current knowledge about their causes, treatments and clinical outcomes.

Original languageEnglish
Pages (from-to)817-848
Number of pages32
JournalFuture Cardiology
Volume9
Issue number6
DOIs
StatePublished - Nov 1 2013

Fingerprint

Cardiomyopathies
Epidemiology
Pediatrics
Muscular Diseases
Heart Transplantation
Therapeutics
Natural History
Practice Guidelines
Myocardium
Chronic Disease
Incidence
Research

Keywords

  • cardiomyopathy
  • heart failure
  • pediatric
  • risk factors
  • transplantation
  • treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Molecular Medicine

Cite this

Lipshultz, S. E., Cochran, T. R., Briston, D. A., Brown, S. R., Sambatakos, P. J., Miller, T. L., ... Wilkinson, J. D. (2013). Pediatric cardiomyopathies: Causes, epidemiology, clinical course, preventive strategies and therapies. Future Cardiology, 9(6), 817-848. https://doi.org/10.2217/fca.13.66

Pediatric cardiomyopathies : Causes, epidemiology, clinical course, preventive strategies and therapies. / Lipshultz, Steven E; Cochran, Thomas R.; Briston, David A.; Brown, Stefanie R.; Sambatakos, Peter J.; Miller, Tracie L; Carrillo, Adriana A.; Corcia, Liat; Sanchez, Janine E; Diamond, Melissa B.; Freundlich, Michael; Harake, Danielle; Gayle, Tamara; Harmon, William G.; Rusconi, Paolo; Sandhu, Satinder K; Wilkinson, James D.

In: Future Cardiology, Vol. 9, No. 6, 01.11.2013, p. 817-848.

Research output: Contribution to journalArticle

Lipshultz, SE, Cochran, TR, Briston, DA, Brown, SR, Sambatakos, PJ, Miller, TL, Carrillo, AA, Corcia, L, Sanchez, JE, Diamond, MB, Freundlich, M, Harake, D, Gayle, T, Harmon, WG, Rusconi, P, Sandhu, SK & Wilkinson, JD 2013, 'Pediatric cardiomyopathies: Causes, epidemiology, clinical course, preventive strategies and therapies', Future Cardiology, vol. 9, no. 6, pp. 817-848. https://doi.org/10.2217/fca.13.66
Lipshultz SE, Cochran TR, Briston DA, Brown SR, Sambatakos PJ, Miller TL et al. Pediatric cardiomyopathies: Causes, epidemiology, clinical course, preventive strategies and therapies. Future Cardiology. 2013 Nov 1;9(6):817-848. https://doi.org/10.2217/fca.13.66
Lipshultz, Steven E ; Cochran, Thomas R. ; Briston, David A. ; Brown, Stefanie R. ; Sambatakos, Peter J. ; Miller, Tracie L ; Carrillo, Adriana A. ; Corcia, Liat ; Sanchez, Janine E ; Diamond, Melissa B. ; Freundlich, Michael ; Harake, Danielle ; Gayle, Tamara ; Harmon, William G. ; Rusconi, Paolo ; Sandhu, Satinder K ; Wilkinson, James D. / Pediatric cardiomyopathies : Causes, epidemiology, clinical course, preventive strategies and therapies. In: Future Cardiology. 2013 ; Vol. 9, No. 6. pp. 817-848.
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