Pearls: Myasthenia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myasthenia gravis is typically an acquired autoimmune disorder in which antibodies are directed at structural components of the neuromuscular junction, most commonly the nicotinic acetylcholine receptor. The clinical manifestations of skeletal muscle weakness are broad. Patients most often report fatigable muscle weakness. The eyelid levators and extraocular muscles are most commonly affected, resulting in symptoms of ptosis and diplopia. Symptoms may be confined to the eyes (ocular myasthenia) or reflect bulbar, limb, or respiratory muscle weakness (generalized myasthenia). The diagnosis is based on a characteristic history and the finding of fatigable muscle weakness on examination, and may be supported by diagnostic tests such as finding elevated titers of acetylcholine receptor or muscle-specific receptor tyrosine kinase (MuSK) antibodies, a positive Tensilon test, a decremental response on slow repetitive nerve stimulation, and abnormal jitter on single fiber electromyography. This article presents a series of pearls to aid in the clinical and laboratory diagnosis of myasthenia gravis, emphasizing key historical features, common and characteristic findings on examination, and potential pitfalls in the use of ancillary diagnostic studies.

Original languageEnglish
Pages (from-to)35-37
Number of pages3
JournalSeminars in Neurology
Volume30
Issue number1
DOIs
StatePublished - Feb 22 2010
Externally publishedYes

Fingerprint

Muscle Weakness
Myasthenia Gravis
Oculomotor Muscles
Edrophonium
Respiratory Muscles
Diplopia
Antibodies
Neuromuscular Junction
Clinical Laboratory Techniques
Nicotinic Receptors
Receptor Protein-Tyrosine Kinases
Electromyography
Cholinergic Receptors
Eyelids
Routine Diagnostic Tests
Skeletal Muscle
Extremities
History
Muscles

Keywords

  • Acquired autoimmune myasthenia gravis
  • Clinical examination
  • Diagnostic tests

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pearls : Myasthenia. / Benatar, Michael G.

In: Seminars in Neurology, Vol. 30, No. 1, 22.02.2010, p. 35-37.

Research output: Contribution to journalArticle

Benatar, Michael G. / Pearls : Myasthenia. In: Seminars in Neurology. 2010 ; Vol. 30, No. 1. pp. 35-37.
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