PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility

Gary W Beecham, Adam C. Naj, John Gilbert, Jonathan L. Haines, Joseph D. Buxbaum, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A recent genome-wide association study and follow-up shows significant association with the protocadherin 11 X-linked (PCDH11X) gene. Carrasquillo et al. (2009) show statistical association with four PCDH11X polymorphisms (rs5984894, rs2573905, rs5941047, rs4568761) in five of seven cohorts. The combined analysis of 2356 cases and 2384 controls showed the strongest association with a P value of 2.2×10 with an allele-specific odds ratio of 1.30 (95% confidence interval, 1.18-1.43) at the rs5984894 polymorphism. We tested for association at these four single nucleotide polymorphisms in two independent datasets and then performed a joint analysis. Although we had adequate power to detect effect sizes with the reported odds ratios, we did not detect association between late-onset Alzheimer disease and the PCDH11X polymorphisms in our dataset of 889 cases and 850 controls, indicating that the PCDH11X association, if not a false positive, is not as strong or generalized as hypothesized earlier.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalPsychiatric Genetics
Volume20
Issue number6
DOIs
StatePublished - Dec 1 2010

Fingerprint

Disease Susceptibility
Alzheimer Disease
Odds Ratio
X-Linked Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Alleles
Confidence Intervals
Datasets
Alzheimer Disease 11
Power (Psychology)

Keywords

  • Alzheimer disease
  • genetic association study
  • PCDH11X

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry

Cite this

PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility. / Beecham, Gary W; Naj, Adam C.; Gilbert, John; Haines, Jonathan L.; Buxbaum, Joseph D.; Pericak-Vance, Margaret A.

In: Psychiatric Genetics, Vol. 20, No. 6, 01.12.2010, p. 321-324.

Research output: Contribution to journalArticle

Beecham, Gary W ; Naj, Adam C. ; Gilbert, John ; Haines, Jonathan L. ; Buxbaum, Joseph D. ; Pericak-Vance, Margaret A. / PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility. In: Psychiatric Genetics. 2010 ; Vol. 20, No. 6. pp. 321-324.
@article{3f4fa02176074ccc923f5c36b1c3e73d,
title = "PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility",
abstract = "Lippincott Williams & Wilkins.",
keywords = "Alzheimer disease, genetic association study, PCDH11X",
author = "Beecham, {Gary W} and Naj, {Adam C.} and John Gilbert and Haines, {Jonathan L.} and Buxbaum, {Joseph D.} and Pericak-Vance, {Margaret A}",
year = "2010",
month = "12",
day = "1",
doi = "10.1097/YPG.0b013e32833b635d",
language = "English",
volume = "20",
pages = "321--324",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility

AU - Beecham, Gary W

AU - Naj, Adam C.

AU - Gilbert, John

AU - Haines, Jonathan L.

AU - Buxbaum, Joseph D.

AU - Pericak-Vance, Margaret A

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Lippincott Williams & Wilkins.

AB - Lippincott Williams & Wilkins.

KW - Alzheimer disease

KW - genetic association study

KW - PCDH11X

UR - http://www.scopus.com/inward/record.url?scp=78049531016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049531016&partnerID=8YFLogxK

U2 - 10.1097/YPG.0b013e32833b635d

DO - 10.1097/YPG.0b013e32833b635d

M3 - Article

C2 - 20523261

AN - SCOPUS:78049531016

VL - 20

SP - 321

EP - 324

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 6

ER -