Patterns of depression in Spanish- and English-speaking patients with Alzheimer's disease

Raymond L. Ownby, Amarilis Acevedo, Dylan G. Harwood, Warren W. Barker, Ranjan Duara

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The purpose of this study was to evaluate whether distinct subtypes of depression could be identified in patients with Alzheimer's disease and, if so, to evaluate the patients in these subgroups. Ratings on the Cornell Scale for Depression in Dementia (CSDD) of 306 patients with Alzheimer's disease, 129 of whom were Spanish- and 177 English-speaking, were subjected to latent class analysis. Four subgroups were identified based on CSDD symptoms. These included an asymptomatic group, groups with mild and more severe typical depression, and a group characterized by prominent anxiety and irritability in addition to sadness. Group differences on demographic, cognitive, clinical, and functional status measures were explored via chi-square tests and analyses of variance. Results show that for some patients with Alzheimer's disease, patterns of symptoms of depression are similar to those in younger adult populations. A distinct subtype may exist, however, with prominent anxiety and irritability.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalJournal of Geriatric Psychiatry and Neurology
Issue number1
StatePublished - Mar 2008


  • Alzheimer's disease
  • Depression
  • Latent class analysis

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology
  • Neuroscience(all)


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