Pattern recognition receptors and central nervous system repair

Kristina A. Kigerl, Juan Pablo P de Rivero Vaccari, W. Dalton Dietrich, Phillip G. Popovich, Robert Keane

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Pattern recognition receptors (PRRs) are part of the innate immune response and were originally discovered for their role in recognizing pathogens by ligating specific pathogen associated molecular patterns (PAMPs) expressed by microbes. Now the role of PRRs in sterile inflammation is also appreciated, responding to endogenous stimuli referred to as "damage associated molecular patterns" (DAMPs) instead of PAMPs. The main families of PRRs include Toll-like receptors (TLRs), Nod-like receptors (NLRs), RIG-like receptors (RLRs), AIM2-like receptors (ALRs), and C-type lectin receptors. Broad expression of these PRRs in the CNS and the release of DAMPs in and around sites of injury suggest an important role for these receptor families in mediating post-injury inflammation. Considerable data now show that PRRs are among the first responders to CNS injury and activation of these receptors on microglia, neurons, and astrocytes triggers an innate immune response in the brain and spinal cord. Here we discuss how the various PRR families are activated and can influence injury and repair processes following CNS injury.

Original languageEnglish
Pages (from-to)5-16
Number of pages12
JournalExperimental Neurology
Volume258
DOIs
StatePublished - Jan 1 2014

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Pattern Recognition Receptors
Central Nervous System
Wounds and Injuries
Innate Immunity
Inflammation
C-Type Lectins
Toll-Like Receptors
Microglia
Astrocytes
Spinal Cord
Neurons
Brain

Keywords

  • Inflammasome
  • Neuroinflammation
  • NOD-like receptors
  • Pattern recognition receptors
  • Spinal cord injury
  • Toll-like receptors

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Pattern recognition receptors and central nervous system repair. / Kigerl, Kristina A.; de Rivero Vaccari, Juan Pablo P; Dalton Dietrich, W.; Popovich, Phillip G.; Keane, Robert.

In: Experimental Neurology, Vol. 258, 01.01.2014, p. 5-16.

Research output: Contribution to journalArticle

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