Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease

Clara Abraham, Maria T. Abreu, Jerrold R. Turner

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammatory bowel disease is characterized by defects in epithelial function and dysregulated inflammatory signaling by lamina propria mononuclear cells including macrophages and dendritic cells in response to microbiota. In this review, we focus on the role of pattern recognition receptors in the inflammatory response as well as epithelial barrier regulation. We explore cytokine networks that increase inflammation, regulate paracellular permeability, cause epithelial damage, up-regulate epithelial proliferation, and trigger restitutive processes. We focus on studies using patient samples as well as speculate on pathways that can be targeted to more holistically treat patients with inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)1602-1616.e6
JournalGastroenterology
Volume162
Issue number6
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • Claudin
  • Genetics
  • IL23
  • JAK-STAT
  • MLCK
  • TNF
  • Tight Junction
  • Toll-Like Receptor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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