Pattern of hearing loss in a rat model of cochlear implantation trauma

Adrien Eshraghi, Marek Polak, Jiao He, Fred F Telischi, Thomas J. Balkany, Thomas R Van De Water

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Hypothesis: Trauma caused by cochlear implant electrode insertion is attributable to the combination of direct physical trauma and the delayed cell death of oxidative stress-injured auditory sensory cells. Background: Histologic evaluation of cochlear implant electrode trauma has demonstrated that the extent of sensory cell losses is proportional to the degree of injury. However, the impact of delayed oxidative stress within injured cochlear tissues and the progressive loss of injured hair cells by way of apoptosis are at present unknown. Methods: Laboratory rats were evaluated for hearing acuity before and after electrode insertion, before and after round window membrane incision only. Hearing was measured before trauma or incision and over the next 7 days. Objective measurements of hearing function were distortion products of otoacoustic emissions (DPOAEs) in the frequency range of 2 to 32 kHz and tone-burst (i.e., 4-32 kHz) evoked auditory brain stem responses (ABRs). Results: For the experimental cochleae, there were progressive increases in ABR thresholds and decreases in ABR amplitudes. The amplitude of the DPOAEs in the experimental cochleae also showed progressive decreases. For the contralateral control and round window membrane surgical control ears, there were no significant changes in either DPOAE or ABR thresholds. Conclusion: These results document a progressive loss of hearing acuity postimplantation and strongly suggest that electrode insertion trauma generated oxidative stress within injured cochlear tissues.

Original languageEnglish
Pages (from-to)442-447
Number of pages6
JournalOtology and Neurotology
Volume26
Issue number3
DOIs
StatePublished - May 1 2005

Fingerprint

Cochlear Implantation
Hearing Loss
Brain Stem Auditory Evoked Potentials
Cochlea
Wounds and Injuries
Electrodes
Hearing
Oxidative Stress
Cochlear Implants
Membranes
Alopecia
Ear
Cell Death
Apoptosis

Keywords

  • Apoptosis
  • Cochlear implantation trauma
  • Delayed hearing loss
  • Hair cell

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)

Cite this

Pattern of hearing loss in a rat model of cochlear implantation trauma. / Eshraghi, Adrien; Polak, Marek; He, Jiao; Telischi, Fred F; Balkany, Thomas J.; Van De Water, Thomas R.

In: Otology and Neurotology, Vol. 26, No. 3, 01.05.2005, p. 442-447.

Research output: Contribution to journalArticle

Eshraghi, Adrien ; Polak, Marek ; He, Jiao ; Telischi, Fred F ; Balkany, Thomas J. ; Van De Water, Thomas R. / Pattern of hearing loss in a rat model of cochlear implantation trauma. In: Otology and Neurotology. 2005 ; Vol. 26, No. 3. pp. 442-447.
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