Pattern of colony-stimulating activity in HL-60 cells after phorbol-ester-induced differentiation

S. L. Perkins, A. A. Yunis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


HL-60 cells secrete an autostimulatory activity (ASA) that appears to be required for their growth in vitro. The purpose of this study was to examine the pattern of colony-stimulating activity in conditioned media of HL-60 after induction of differentiation by the phorbol ester phorbol-12-myristate-13-acetate (PMA). PMA-induced differentiation to monocyte-macrophage cells was accompained by persistence of ASA secretion and the appearance of new species of colony-stimulating activities similar in properties to human CSF I and CSF II. Thus the secretion of ASA by HL-60 appears to be a characteristic property of these cells that is maintained after terminal differentiation.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalExperimental Hematology
Issue number5
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research


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