Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma

Tong Wang, Sabrina C. Wentz, Natalie L. Ausborn, M. Kay Washington, Nipun Merchant, Zhiguo Zhao, Yu Shyr, A. Bapsi Chakravarthy, Fen Xia

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVES: The tumor-suppressor breast cancer susceptibility gene 1 (BRCA1) is a nuclear-cytoplasmic shuttling protein that when in the nucleus is required for DNA repair whereas when in the cytoplasm is important in activating cell death processes. Although BRCA1 mutations have been shown to be associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC), its role in disease progression is yet to be determined. We hypothesized that BRCA1 expression pattern could be used as a prognostic biomarker. METHODS: Sixty-seven patients who underwent resections for PDAC were included. A tissue microarray was constructed, stained with antibodies to BRCA1, and scored for intensity and subcellular location. Univariate and multivariate statistical analyses were performed. RESULTS: An increase in cytosolic BRCA1 distribution was associated with higher pathologic stage (P = 0.006). Nuclear-cytosolic BRCA1 distribution was associated with a decrease in recurrence-free survival with a hazards ratio of 1.4 (P = 0.059). Decreased BRCA1 intensity was associated with higher pathologic stage (P = 0.027), but BRCA1 intensity was not associated with overall survival or recurrence-free survival. CONCLUSIONS: Our results demonstrate a possible association of BRCA1 expression pattern with pathologic stage, implying a potential role of BRCA1 in PDAC development and progression.

Original languageEnglish (US)
Pages (from-to)977-982
Number of pages6
JournalPancreas
Volume42
Issue number6
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Neoplasm Genes
Adenocarcinoma
Biomarkers
Breast Neoplasms
Gene Expression
Survival
Recurrence
DNA Repair
Disease Progression
Cytoplasm
Cell Death
Multivariate Analysis
Mutation
Antibodies

Keywords

  • BRCA1 expression
  • BRCA1 localization

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma. / Wang, Tong; Wentz, Sabrina C.; Ausborn, Natalie L.; Washington, M. Kay; Merchant, Nipun; Zhao, Zhiguo; Shyr, Yu; Chakravarthy, A. Bapsi; Xia, Fen.

In: Pancreas, Vol. 42, No. 6, 08.2013, p. 977-982.

Research output: Contribution to journalArticle

Wang, Tong ; Wentz, Sabrina C. ; Ausborn, Natalie L. ; Washington, M. Kay ; Merchant, Nipun ; Zhao, Zhiguo ; Shyr, Yu ; Chakravarthy, A. Bapsi ; Xia, Fen. / Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma. In: Pancreas. 2013 ; Vol. 42, No. 6. pp. 977-982.
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