Pattern electroretinograms (PERGs) in response to equiluminant red-green and blue-yellow gratings as diagnostic tool to investigate retinal ganglion cell subsystem involvement

F. Sartucci, L. Murri, A. Filippi, N. Origlia, L. Domenici, C. Orsini, V. Porciatti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: to better characterize the properties of chromatic pattern Electroretinograms (ChPERGs) and establish normative value for a set of stimuli able to elicit robust and reliable responses, suitable for clinical application in neurological disorders. Materials and methods: PERGs were recorded in response to both equiluminant red-green (R-G) and blue-yellow (B-Y) as well as luminance (Lum) contrast stimuli (yellow-black, Y-Bk), known to emphasize activity of the parvo-, konio- and magnocellular ganglion-cell subsystem respectively. Results: PERG responses could be reliably recorded either in normal observers as well in patients and signal were reproducible. Responses exhibited a typical positive-negative (P1-N1) waveform for both R-G and B-Y stimuli and had a smaller amplitude and a longer latency that Lum ones. Conclusions: these results complement previous studies aimed at characterizing the properties of ChPERGs; in addition normative data are provided for a set of stimulus characteristics suitable for the clinical routine; furthermore pathognomonic changes in main neurological diseases are reported.

Original languageEnglish (US)
Pages (from-to)4-7
Number of pages4
JournalInternal Medicine Clinical and Laboratory
Volume13-14
Issue number1-3
StatePublished - Jan 1 2005

Keywords

  • Chromatic contrast
  • Idiopathic Parkinson's disease
  • konio- and magnocellulare subsystem
  • Luminance contrast
  • Multiple sclerosis
  • Multiple system atrophy
  • Parvo-
  • Pattern electroretinogram

ASJC Scopus subject areas

  • Internal Medicine

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