Abstract
Objective: to better characterize the properties of chromatic pattern Electroretinograms (ChPERGs) and establish normative value for a set of stimuli able to elicit robust and reliable responses, suitable for clinical application in neurological disorders. Materials and methods: PERGs were recorded in response to both equiluminant red-green (R-G) and blue-yellow (B-Y) as well as luminance (Lum) contrast stimuli (yellow-black, Y-Bk), known to emphasize activity of the parvo-, konio- and magnocellular ganglion-cell subsystem respectively. Results: PERG responses could be reliably recorded either in normal observers as well in patients and signal were reproducible. Responses exhibited a typical positive-negative (P1-N1) waveform for both R-G and B-Y stimuli and had a smaller amplitude and a longer latency that Lum ones. Conclusions: these results complement previous studies aimed at characterizing the properties of ChPERGs; in addition normative data are provided for a set of stimulus characteristics suitable for the clinical routine; furthermore pathognomonic changes in main neurological diseases are reported.
| Original language | English |
|---|---|
| Pages (from-to) | 4-7 |
| Number of pages | 4 |
| Journal | Internal Medicine Clinical and Laboratory |
| Volume | 13-14 |
| Issue number | 1-3 |
| State | Published - Jan 1 2005 |
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Keywords
- Chromatic contrast
- Idiopathic Parkinson's disease
- konio- and magnocellulare subsystem
- Luminance contrast
- Multiple sclerosis
- Multiple system atrophy
- Parvo-
- Pattern electroretinogram
ASJC Scopus subject areas
- Internal Medicine
Cite this
Pattern electroretinograms (PERGs) in response to equiluminant red-green and blue-yellow gratings as diagnostic tool to investigate retinal ganglion cell subsystem involvement. / Sartucci, F.; Murri, L.; Filippi, A.; Origlia, N.; Domenici, L.; Orsini, C.; Porciatti, Vittorio.
In: Internal Medicine Clinical and Laboratory, Vol. 13-14, No. 1-3, 01.01.2005, p. 4-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pattern electroretinograms (PERGs) in response to equiluminant red-green and blue-yellow gratings as diagnostic tool to investigate retinal ganglion cell subsystem involvement
AU - Sartucci, F.
AU - Murri, L.
AU - Filippi, A.
AU - Origlia, N.
AU - Domenici, L.
AU - Orsini, C.
AU - Porciatti, Vittorio
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Objective: to better characterize the properties of chromatic pattern Electroretinograms (ChPERGs) and establish normative value for a set of stimuli able to elicit robust and reliable responses, suitable for clinical application in neurological disorders. Materials and methods: PERGs were recorded in response to both equiluminant red-green (R-G) and blue-yellow (B-Y) as well as luminance (Lum) contrast stimuli (yellow-black, Y-Bk), known to emphasize activity of the parvo-, konio- and magnocellular ganglion-cell subsystem respectively. Results: PERG responses could be reliably recorded either in normal observers as well in patients and signal were reproducible. Responses exhibited a typical positive-negative (P1-N1) waveform for both R-G and B-Y stimuli and had a smaller amplitude and a longer latency that Lum ones. Conclusions: these results complement previous studies aimed at characterizing the properties of ChPERGs; in addition normative data are provided for a set of stimulus characteristics suitable for the clinical routine; furthermore pathognomonic changes in main neurological diseases are reported.
AB - Objective: to better characterize the properties of chromatic pattern Electroretinograms (ChPERGs) and establish normative value for a set of stimuli able to elicit robust and reliable responses, suitable for clinical application in neurological disorders. Materials and methods: PERGs were recorded in response to both equiluminant red-green (R-G) and blue-yellow (B-Y) as well as luminance (Lum) contrast stimuli (yellow-black, Y-Bk), known to emphasize activity of the parvo-, konio- and magnocellular ganglion-cell subsystem respectively. Results: PERG responses could be reliably recorded either in normal observers as well in patients and signal were reproducible. Responses exhibited a typical positive-negative (P1-N1) waveform for both R-G and B-Y stimuli and had a smaller amplitude and a longer latency that Lum ones. Conclusions: these results complement previous studies aimed at characterizing the properties of ChPERGs; in addition normative data are provided for a set of stimulus characteristics suitable for the clinical routine; furthermore pathognomonic changes in main neurological diseases are reported.
KW - Chromatic contrast
KW - Idiopathic Parkinson's disease
KW - konio- and magnocellulare subsystem
KW - Luminance contrast
KW - Multiple sclerosis
KW - Multiple system atrophy
KW - Parvo-
KW - Pattern electroretinogram
UR - http://www.scopus.com/inward/record.url?scp=34249981753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249981753&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:34249981753
VL - 13-14
SP - 4
EP - 7
JO - Internal Medicine Clinical and Laboratory
JF - Internal Medicine Clinical and Laboratory
SN - 1590-9271
IS - 1-3
ER -