Pattern electroretinogram progression in glaucoma suspects

Lori M. Ventura, Iuri Golubev, William J Feuer, Vittorio Porciatti

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

PURPOSE:: To prospectively monitor progressive changes of retinal ganglion cell function in early glaucoma using the pattern electroretinogram (PERG). METHODS:: Fifty-nine patients enrolled as glaucoma suspects were observed untreated over an average of 5.7±1.4 years, during which they were tested with PERG (PERGLA paradigm) and standard automated perimetry (SAP) 2 times per year. PERG amplitude and phase were normalized for physiological age-related changes, and linear regressions fitted to the data to calculate progression slopes (signal), slope SE (noise), and corresponding signal-to-noise ratios (SNR=slope÷SE). Linear regressions were also used to fit SAP global indices mean deviation (MD) and pattern standard deviation (PSD). RESULTS:: On average, progression slopes of PERG amplitude/phase were skewed toward negative values, their mean being significantly (P<0.01) different from zero. In contrast, mean slopes of SAP-MD and PSD were not significantly different from zero. SNRs were higher for PERG than SAP (P<0.01). A substantial number of eyes displayed significant (P<0.05) progression of PERG amplitude (15% to 20%) or PERG phase (16% to 25%). Fewer eyes displayed significant progression of SAP-MD (0% to 2%) or SAP-PSD (4% to 8%). CONCLUSIONS:: The PERG displayed clear longitudinal loss of signal (diminished amplitude, phase delay, or both) in a substantial number of eyes of patients, indicating progressive deterioration of retinal ganglion cell function. Progression of SAP global indices MD and PSD was found in a relatively smaller number of eyes. It remains to be established whether PERG progression has predictive value for developing visual dysfunction.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Glaucoma
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2013

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Ocular Hypertension
Visual Field Tests
Retinal Ganglion Cells
Linear Models
Signal-To-Noise Ratio
Glaucoma
Noise

Keywords

  • Glaucoma
  • Pattern electroretinogram
  • Progression
  • Retinal ganglion cell function
  • Visual field

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pattern electroretinogram progression in glaucoma suspects. / Ventura, Lori M.; Golubev, Iuri; Feuer, William J; Porciatti, Vittorio.

In: Journal of Glaucoma, Vol. 22, No. 3, 01.03.2013, p. 219-225.

Research output: Contribution to journalArticle

Ventura, Lori M. ; Golubev, Iuri ; Feuer, William J ; Porciatti, Vittorio. / Pattern electroretinogram progression in glaucoma suspects. In: Journal of Glaucoma. 2013 ; Vol. 22, No. 3. pp. 219-225.
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