Pattern electroretinogram in glaucoma

Lori M. Ventura, Vittorio Porciatti

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Purpose of review: Several studies have shown that the pattern electroretinogram, a direct, objective method of measuring retinal ganglion cell function, is altered early in ocular hypertension and glaucoma. Renewed interest in the pattern electroretinogram for early detection of pre-perimetric glaucoma has been sparked by noninvasive and reproducible methods of recording using skin electrodes. Recent findings: With the noninvasive pattern electroretinogram, response abnormalities have been detected in up to 50% of glaucoma suspects with normal standard perimetry. In early glaucoma (with either normal or high intraocular pressure), a reduction of intraocular pressure has sometimes yielded improvement in pattern electroretinogram amplitude. A prolonged steady-state stimulus presentation reduces the pattern electroretinogram amplitude and increases optic nerve blood flow in normal subjects, suggesting that sustained activity of retinal ganglion cells is physiologically associated with autoregulatory changes of the neural-vascular system. It is unknown whether this autoregulation is altered in glaucoma. The multifocal pattern electroretinogram does not seem to have an advantage over the pattern electroretinogram in the early detection of glaucoma. The photopic negative response of the diffuse flash electroretinogram has shown changes in glaucoma, but may not be able to detect retinal dysfunction in normal tension glaucoma. Summary: The pattern electroretinogram is a noninvasive, direct, objective method that may be useful to clinicians in detecting early retinal ganglion cell dysfunction in glaucoma suspects. The pattern electroretinogram may also optimize treatment strategies based on improvement of retinal ganglion cell function.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalCurrent Opinion in Ophthalmology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2006

Fingerprint

Glaucoma
Retinal Ganglion Cells
Ocular Hypertension
Intraocular Pressure
Low Tension Glaucoma
Visual Field Tests
Optic Nerve
Blood Vessels
Electrodes
Homeostasis
Skin

Keywords

  • Glaucoma
  • Neuroprotection
  • Pattern electroretinogram
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pattern electroretinogram in glaucoma. / Ventura, Lori M.; Porciatti, Vittorio.

In: Current Opinion in Ophthalmology, Vol. 17, No. 2, 01.04.2006, p. 196-202.

Research output: Contribution to journalArticle

Ventura, Lori M. ; Porciatti, Vittorio. / Pattern electroretinogram in glaucoma. In: Current Opinion in Ophthalmology. 2006 ; Vol. 17, No. 2. pp. 196-202.
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